Abstract
Mice have three functional α-globin genes and two closely related pseudogenes1–5. In BALB/c mice, the functional genes are known to be clustered on chromosome 11, but the pseudo-genes, designated αψ3 and αψ4, are located on chromosomes 15 and 17, respectively5. One of the pseudogenes, αψ3, has precisely lost the intervening sequences characteristic of the functional genes3,4, as if it had been generated from a processed RNA intermediate. It has been suggested that retroviral functions could have been instrumental in the formation of this ‘spliceless’ pseudogene6 and its integration at a novel chromosomal locus5. We report here that retrovirus-like elements are located on both sides of the αψ3 gene.
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Lueders, K., Leder, A., Leder, P. et al. Association between a transposed α-globin pseudogene and retrovirus-like elements in the BALB/c mouse genome. Nature 295, 426–428 (1982). https://doi.org/10.1038/295426a0
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DOI: https://doi.org/10.1038/295426a0
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