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Lysis gene expression of RNA phage MS2 depends on a frameshift during translation of the overlapping coat protein gene

Nature volume 295, pages 35–41 (1982)Cite this article

Abstract

Translation of the lysis cistron of MS2 RNA requires a frameshift of ribosomes reading the upstream coat protein mRNA. The out-of-phase fraction of ribosomes terminates at either one of two nonsense codons just preceding the lysis cistron. Termination is followed by initiation at the start codon of the lysis protein message.

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Author notes

  1. J. van Duin

    Present address: Thimann Laboratories, University of California, Division of Natural Sciences, Santa Cruz, California, 95064, USA

  2. E. Remaut and W. Fiers: Laboratory for Molecular Biology, University of Ghent, Ghent, Belgium

Authors and Affiliations

  1. Department of Biochemistry, University of Leiden, PO Box 9505, 2300, RA, Leiden, The Netherlands

    R. A. Kastelein, E. Remaut, W. Fiers & J. van Duin

Authors
  1. R. A. Kastelein
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  2. E. Remaut
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  3. W. Fiers
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  4. J. van Duin
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Kastelein, R., Remaut, E., Fiers, W. et al. Lysis gene expression of RNA phage MS2 depends on a frameshift during translation of the overlapping coat protein gene. Nature 295, 35–41 (1982). https://doi.org/10.1038/295035a0

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