Abstract
The S-100 antigen1 is generally considered to be unique to the nervous system, where it is found primarily in the cytoplasm and nucleus of glial cells, both in soluble and bound form2,3. It belongs to the family of acidic Ca2+-binding proteins4. In phylogenesis, S-100 conserves a close immunological relationship between different species, and during ontogenesis the pattern of its accumulation parallels the functional maturation of the nervous system2,3, although its biological role remains to be clarified. Recently, S-100 has been found in cells of non-nervous organs (interstitial cells of the pineal gland5, stellate cells of the adenohypophysis6,7 and satellite cells of the adrenal medulla8), and in cultured malignant human melanomas9. We report here the presence of S-100 in normal human skin, where the antigen seems to be located specifically in melanocytes and in cells with morphological features of Langerhans cells.
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Cocchia, D., Michetti, F. & Donato, R. Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin. Nature 294, 85–87 (1981). https://doi.org/10.1038/294085a0
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DOI: https://doi.org/10.1038/294085a0
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