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Calcium and the control of synaptic strength by learning

Nature volume 293, pages 697–700 (1981)Cite this article

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References

  1. Konorski, J. Conditioned Reflexes and Neuron Organization (Cambridge University Press, 1978).

    Google Scholar 

  2. Gopfert, H. & Schaefer, H. Pflügers Arch. ges. Physiol. 239 597 (1938).

    Article  Google Scholar 

  3. Fatt, P. & Katz, B. J. Physiol. Lond. 115, 320 (1951).

    Article  CAS  Google Scholar 

  4. Feng, T.P. Chin. J. Physiol. 16, 341 (1941).

    CAS  Google Scholar 

  5. Lloyd, D.P.C. J. gen. Physiol. 33, 147 (1949).

    Article  CAS  Google Scholar 

  6. Frank, K. & Fuortes, M.G.F. Fedn Proc. 16, 39 (1957).

    Google Scholar 

  7. Dudel, J. & Kuffler, S.W. J. Physiol., Lond. 155, 514–543 (1961).

    Article  CAS  Google Scholar 

  8. Kandel, E.R. & Tauc, L. Nature 202, 145 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Castellucci, V.F., Pinsker, H., Kuperfmann, I. & Kandel, E.R. Science 167, 1745 (1970).

    Article  ADS  CAS  Google Scholar 

  10. Zucker, R.S. J. Neurophysiol. 35, 599 (1972). Zucker, R.S. J. Neurophysiol. 35, 621 (1972).

    Article  CAS  Google Scholar 

  11. Krasne, F.B. in Invertebrate Learning Vol.2 (eds Corning, W.C., Dyal, J.A. & Willows, A.O.D.) 49 (Plenum, New York, 1973).

    Book  Google Scholar 

  12. Castellucci, V. & Kandel, E.R. Proc. natn. Acad. Sci. U.S.A. 71, 5004 (1974).

    Article  ADS  CAS  Google Scholar 

  13. Castellucci, V.F. & Kandel, E.R. Science 194, 1176 (1976).

    Article  ADS  CAS  Google Scholar 

  14. Liley, A.W. J. Physiol., Lond 133, 571 (1956).

    Article  CAS  Google Scholar 

  15. Katz, B. & Miledi, R. J. Physiol., Lond. 189, 535 (1967).

    Article  CAS  Google Scholar 

  16. Katz, B. & Miledi, R. J. Physiol., Lond. 195, 481 (1968).

    Article  CAS  Google Scholar 

  17. Rahamimoff, R. J. Physiol., Lond. 195, 471 (1968).

    Article  CAS  Google Scholar 

  18. Alnaes, E. & Rahamimoff, R. J. Physiol., Lond. 248, 285 (1975).

    Article  CAS  Google Scholar 

  19. Geduldig, D. & Junge, D. J. Physiol., Lond. 199, 347 (1968).

    Article  CAS  Google Scholar 

  20. Geduldig, D. & Gruener, R. J. Physiol., Lond. 211, 217 (1970).

    Article  CAS  Google Scholar 

  21. Stinnakre, J. & Tauc, L. Nature new Biol. 242, 113 (1973).

    Article  CAS  Google Scholar 

  22. Llinas, R., Steinberg, I. & Walton, K. Proc. natn. Acad. Sci. U.S.A. 73, 2918 (1976).

    Article  ADS  CAS  Google Scholar 

  23. Klein, M. & Kandel, E.R. Proc. natn. Acad. Sci. U.S.A. 75, 3512 (1978).

    Article  ADS  CAS  Google Scholar 

  24. Shimahara, T. & Tauc, L. J. Physiol. Lond. 247, 299 (1975).

    Article  CAS  Google Scholar 

  25. Shimahara, T. & Peretz, B. Nature 273, 158 (1978).

    Article  ADS  CAS  Google Scholar 

  26. Shapiro, E., Castellucci, V.F. & Kandel, E.R. Proc. natn. Acad. Sci. U.S.A. 77, 629 (1980).

    Article  ADS  CAS  Google Scholar 

  27. Kretz, R., Shapiro, E. & Kandel, E.R. Soc. Neurosci. Abstr. 6, 602 (1980).

    Google Scholar 

  28. Kretz, R., Shapiro, E. & Kandel, E.R. Soc. Neurosci. Abstr. 7 (in the press).

  29. Klein, M., Shapiro, E. & Kandel, E.R. J. exp. Biol 89, 117 (1980).

    CAS  PubMed  Google Scholar 

  30. Shapiro, E., Castellucci, V.F. & Kandel, E.R. Proc. natn. Acad. Sci. U.S.A. 77, 1185 (1980).

    Article  ADS  CAS  Google Scholar 

  31. Mudge, A.W., Leeman, S.E. & Fischbach, G.D. Proc. natn. Acad. Sci. U.S.A. 76, 526 (1979).

    Article  ADS  CAS  Google Scholar 

  32. Klein, M. & Kandel, E.R. Proc. natn. Acad. Sci. U.S.A. 77, 6912 (1980).

    Article  ADS  CAS  Google Scholar 

  33. Meech, R. Comp. Biochem. Physiol. A42, 493 (1972).

    Article  CAS  Google Scholar 

  34. Brehm, P. & Eckert, R. Science 202, 1203 (1978).

    Article  ADS  CAS  Google Scholar 

  35. Reuter, H. A. Rev. Physiol. 41, 413 (1979).

    Article  CAS  Google Scholar 

  36. Tillotson, D. Proc. natn. Acad. Sci. U.S.A. 76, 1497 (1979).

    Article  ADS  CAS  Google Scholar 

  37. Castellucci, V.F. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7492 (1980).

    Article  ADS  CAS  Google Scholar 

  38. Castellucci et al. Soc. Neurosci. Abstr. 11, 836 (1981).

    Google Scholar 

  39. Sutherland, E.W., Rall, T.W. & Menon, T. J. biol. Chem. 237, 1220 (1962).

    CAS  PubMed  Google Scholar 

  40. Hartzell, H.C. Nature 291, 539 (1981).

    Article  ADS  CAS  Google Scholar 

  41. Greengard, P. Cyclic Nucleotides, Phosphorylated Proteins and Neuronal Function (Raven Press, 1981).

    Google Scholar 

  42. Grundfest, H. Physiol. Rev. 37, 337 (1957).

    Article  CAS  Google Scholar 

  43. Grundfest, H. in Synaptic Transmission and Neuronal Interaction (ed. Bennett, M.V.L. 1–21 (Raven, New York, 1974).

    Google Scholar 

  44. Kordas, M. J. Physiol., Lond. 204, 493 (1969).

    Article  CAS  Google Scholar 

  45. Dionne, V.E. & Stevens, C.F. J. Physiol., Lond. 251, 245 (1975).

    Article  CAS  Google Scholar 

  46. Magelby, K.L. & Stevens, C.F. J. Physiol., Lond. 223, 151 (1972).

    Article  Google Scholar 

  47. Tsien, R.W. Adv. Cyclic Nucleotide Res. 8, 363–420 (1977).

    CAS  Google Scholar 

  48. Kuba, K. & Koketsu, K. Brain Res. 89, 166 (1975).

    Article  CAS  Google Scholar 

  49. Wilson, W.A. & Wachtel, H. Science 202, 772 (1978).

    Article  ADS  CAS  Google Scholar 

  50. Brown, D.A. & Adams, P.R. Nature 283, 673, 676 (1980).

    Article  ADS  CAS  Google Scholar 

  51. Kandel, E.R. & Schwartz, J.H. Science (in the press).

  52. Del Castillo, J. & Katz, B. J. Physiol, Lond. 124, 560 (1954).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Neurobiology and Behaviour, College of Physicians and Surgeons of Columbia University, New York

    E.R. Kandel

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Kandel, E. Calcium and the control of synaptic strength by learning. Nature 293, 697–700 (1981). https://doi.org/10.1038/293697a0

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