Abstract
We have recently isolated and sequenced a neuropeptide from the freshwater coelenterate hydra (Hydra attenuata), which was named head activator because it controls head-specific growth and differentiation processes1–4. The head activator is an undecapeptide of molecular weight 1,142, with the sequence pGlu-Pro-Pro-Gly-Gly-Ser-Lys-Val-Ile-Leu-Phe. We have also previously purified a peptide from mammalian brain and intestine which has similar biological and chemical properties to those of the head activator from hydra5,6. Here, we present evidence that a peptide of identical amino acid sequence to the head activator can be isolated from human hypothalamus, bovine hypothalamus and rat intestine. This is the first example of a neuropeptide conserved structurally intact from a most primitive nervous system to the advanced nervous system represented in humans.
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References
Schaller, H. C. & Bodenmüller, H. Proc. natn. Acad. Sci. U.S.A. (in the press).
Grimmelikhuijzen, C. J. P. & Schaller, H. C. Trends biochem. Sci. 4, 265–267 (1979).
Schaller, H. C., Schmidt, T. & Grimmelikhuijzen, C. J. P. Wilhelm Roux's Arch. dev. Biol. 186, 139–149 (1979).
Schaller, H. C. in Molecular Control of Proliferation and Differentiation (eds Papacon-stantinov, J. & Rutter, W. J.) 231–241 (Academic, New York, 1978).
Schaller, H. C. J. Neurochem. 25, 187–188 (1975).
Bodenmüller, H., Schaller, H. C. & Darai, G. Neurosci. Lett. 16, 71–74 (1980).
Gray, W. R. Meth. Enzym. 25, 121–138 (1972).
Carraway, R. & Leeman, S. J. biol. Chem. 248, 6854–6861 (1973).
Birr, C., Zachmann, B., Bodenmüller, H. & Schaller, H. C. FEBS Lett. (in the press).
Gray, W. R. & Smith, I. F. Analyt. Biochem. 33, 36–42 (1970).
Zwilling, R., Dörsam, H., Torff, H. I. & Rödl, I. FEBS Lett. 127, 75–78 (1981).
Schaller, H. C. & Gierer, A. J. Embryol. exp. Morph. 29, 39–52 (1973).
Pearse, A. G. E. Nature 262, 92–94 (1976).
Stewart, J. M. & Channabassavaik, K. Fedn Proc. 38, 2302–2308 (1979).
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Bodenmüller, H., Schaller, H. Conserved amino acid sequence of a neuropeptide, the head activator, from coelenterates to humans. Nature 293, 579–580 (1981). https://doi.org/10.1038/293579a0
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DOI: https://doi.org/10.1038/293579a0
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