Abstract
It is widely accepted that B cells possess two distinct receptors. One is the surface immunoglobiilin that recognizes the antigenic determinant; the other transmits the signals for proliferation and differentiation of the B cells after receiving differentiation stimuli mediated by a soluble factor derived from helper T cells. Previously1–4, we demonstrated that the responsivity of B cells to T cell-replacing factor (TRF) was under X-chromosome control, as determined by genetic analysis of the TRF-nonres-ponsiveness of B cells from DBA/ 2Ha mice. An X-linked B-cell defect of DBA/2Ha mice to TRF seemed to be due to the absence of an acceptor site(s). We have immunized the defective (DBA/2Ha♀×BALB/c♂)F1 male mice with antigen-primed parental BALB/c splenic B cells. The resulting alloantiserum preferentially inhibited the B-cell response mediated in vitro by TRF added continuously to the culture. We report here that this antiserum, which presumably contains antibody against the putative TRF-acceptor site, augments primary IgM responses to simultaneously administered suboptimal doses of heterologous erythrocytes injected into TRF high-responder animals. These augmented IgM-PFC (plaque -forming cell) responses were also observed in other X-Iinked B-cell defective CBA/N mice, but not in TRF low-responder DB A/2Ha mice, suggesting that the putative TRF-acceptor site(s) functionally detectable by this antiserum is distinct from the Lyb 3 and Lyb 5 components.
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References
Takatsu, K., Tominaga, A. & Hamaoka, T. J. Immun. 124, 2414–2422 (1980).
Tominaga, A., Takatsu, K. & Hamaoka, T. J. Immun. 124, 2423–2429 (1980).
Takatsu, K., Tanaka, K., Tominaga, A., Kumahara, Y. & Hamaoka, T. J. Immun. 125, 2646–2653 (1980).
Takatsu, K., Tanaka, K., Tominaga, A. & Hamaoka, T. in B Lymphocytes in the Immune Response: Functional, Developmental, and Interactive Properties (eds Klinman, N. R., Mosier, D. E., Scher, I. & Vitetta, E. S.) 331–338 (Elsevier, Amsterdam, 1981).
Huber, B., Gershon, R. K. & Cantor, H. J. exp. Med. 145, 10–20 (1977).
Ahmed, A. et al. J. exp. Med. 145, 101–110 (1977).
Subbarao, B. et al. J. exp. Med. 149, 495–506 (1979).
Mosier, D. E., Mond, J. J. & Goldings, E. A. J. Immun. 119, 1874–1878 (1977).
Mond, J. J., Scher, I., Mosier, D. E., Baese, M. & Paul, W. E. Eur. J. Immun. 8, 457–463 (1978).
Parker, D. C., Fothergill, J. J. & Wadsworth, D. J. Immun. 123, 931–941 (1979).
Ahmed, A. & Sher, I. in B Lymphocytes in the Immune Response (eds Cooper, M., Mosier, D., Sher, I. & Vitetta, E.) 117 (Elsevier, Amsterdam, 1979).
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Takatsu, K., Sano, Y., Tomita, S. et al. Antibody against T cell-replacing factor acceptor site(s) augments in vivo primary IgM responses to suboptimal doses of heterologous erythrocytes. Nature 292, 360–362 (1981). https://doi.org/10.1038/292360a0
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DOI: https://doi.org/10.1038/292360a0
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