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Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behaviour

Nature volume 292, pages 351–352 (1981)Cite this article

Abstract

Rats with unilateral lesions of substantia nigra pars compacta (SN), the area of the brain containing most dopamine-containing neurones, are a widely recognized animal model of Parkinson's disease1–4. When given dopamine agonists such as apomorphine, such rats rotate in a direction contralateral to the lesion, presumably because of the development of supersensitive dopamine receptors in the striatum ipsilateral to the lesion. When grafts of embryonic SN are placed in the lateral ventricle5,6, or into a transplant cavity7 adjacent to the striatum in animals with SN lesions, this rotational behaviour has been shown to decrease. Histochemical examinations have shown that axons from the grafts have grown into the striatum5–7, and biochemical measurements indicate that dopamine concentrations are increased in areas of the striatum adjacent to the SN grafts6. Nevertheless, an obvious problem with this technique, both for basic research and possible clinical applications, is the requirement for fetal central nervous donor tissue. We now describe how grafts of adrenal medulla can be used with similar effects, involving chromaffin cells.

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Author notes

  1. Barry J. Hoffer: Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA

  2. Lars Olson and Ake Seiger: Department of Histology, Karolinska Institute 10401, Stockholm, Sweden

Authors and Affiliations

  1. Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Washington DC, 20032, USA

    William J. Freed, John M. Morihisa, Eleanor Spoor, Barry J. Hoffer, Lars Olson, Ake Seiger & Richard Jed Wyatt

Authors
  1. William J. Freed
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  2. John M. Morihisa
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  3. Eleanor Spoor
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  4. Barry J. Hoffer
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  5. Lars Olson
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  6. Ake Seiger
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  7. Richard Jed Wyatt
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Freed, W., Morihisa, J., Spoor, E. et al. Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behaviour. Nature 292, 351–352 (1981). https://doi.org/10.1038/292351a0

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