Abstract
A series of genes on the 17th chromosome of the mouse, called the major histocompatibility complex, has critical roles in the immune response. The classical transplantation antigens (or H–2 antigens) are encoded by genes located in several loci of this complex—H–2K, H–2D and H–2L (refs 1, 2; Fig. 1). The antigens are cell-surface glycoproteins consisting of a single polypeptide chain of about 350 amino acids, non-covalently associated to a shorter polypeptide chain, β2-microglobulin, which is not encoded by the 17th chromosome. Within a given H–2 haplotype, H–2K, -D or -L antigens differ by discrete antigenic sites, probably due to changes in their amino acid sequences3. As many as 50 alleles have been found for each K and D locus in the laboratory mouse; thus H–2 loci are very polymorphic2. We report here a preliminary study of the structure of H–2 genes, in which the number of H–2-related sequences in the mouse genome has been estimated from the number of DNA fragments able to hybridize specifically with a cDNA carrying an H–2 sequence.
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Cami, B., Brégégère, F., Abastado, J. et al. Multiple sequences related to classical histocompatibility antigens in the mouse genome. Nature 291, 673–675 (1981). https://doi.org/10.1038/291673a0
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DOI: https://doi.org/10.1038/291673a0
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