Abstract
One of the central questions of Epstein-Barr (EB) virus biology concerns the nature of the asymptotic carrier state1,2 whereby the virus, which in vitro transforms B cells into permanent lymphoblastoid cell lines with such efficiency3,4, is harboured for life in the B lymphoid tissues of all previously-infected (seropositive) individuals5. It seems highly probable that this persistent infection is primarily controlled by memory T cells (cytotoxic precursors) specifically primed to the EB virus-induced lymphocyte-detected membrane antigen LYDMA6–9. Thus the degree to which the infection can progress without interruption in individual B cells of the immune host will depend upon the timing of LYDMA expression relative to that of other viral gene functions. We now demonstrate that during EB virus-induced B cell transformation in vitro LYDMA is expressed on the cell surface soon after the appearance of the virus-associated nuclear antigen EBNA10 and coincident with, but not dependent upon, the initiation of cellular DNA synthesis. This suggests that in the lymphoid tissues of the infected host, immunological control over virus-B cell interactions can be exercised early in the cycle at the very onset of virus-induced cell proliferation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Epstein, M. A. & Achong, B. G. A. Rev. Microbiol. 31, 421–445 (1977).
Klein, G. Cancer 45, 2486–2499 (1980).
Henle, W., Diehl, V., Kohn, G., zur Hausen, H. & Henle, G. Science 157, 1064–1065 (1967).
Pope, J. H., Horne, M. K. & Scott, W. Int. J. Cancer 3, 857–866 (1968).
Nilsson, K., Klein, G., Henle, W. & Henle, G. Int. J. Cancer 8, 443–450 (1971).
Moss, D. J., Rickinson, A. B. & Pope, J. H. Int. J. Cancer 22, 662–668 (1978).
Rickinson, A. B., Moss, D. J. & Pope, J. H. Int. J. Cancer 23, 610–617 (1979).
Moss, D. J., Rickinson, A. B. & Pope, J. H. Int. J. Cancer 23, 618–625 (1979).
Rickinson, A. B., Wallace, L. E. & Epstein, M. A. Nature 283, 865–867 (1980).
Reedman, B. M. & Klein, G. Int. J. Cancer 11, 499–520 (1973).
Rickinson, A. B., Moss, D. J., Allen, D. J., Wallace, L. E., Rowe, M. & Epstein, M. A. Int. J. Cancer (in the press).
Misko, I. S., Moss, D. J. & Pope, J. H. Proc. natn. Acad. Sci. U.S.A. 77, 4247–4250 (1980).
Moss, D. J., Wallace, L. E., Rickinson, A. B. & Epstein, M. A. Eur. J. Immun. (in the press).
Wallace, L. E., Moss, D. J., Rickinson, A. B., McMichael, A. J. & Epstein, M. A. Eur. J. Immun. (in the press).
Rickinson, A. B., Moss, D. J., Wallace, L. E., Rowe, M., Misko, I. S., Epstein, M. A. & Pope, J. H. Cancer Res. (in the press).
Svedmyr, E. & Jondal, M. Proc. natn. Acad. Sci. U.S.A. 72, 1622–1626 (1975).
Royston, I., Sullivan, J. L., Periman, P. O. & Perlin, E. New Engl. J. Med. 293, 1159–1163 (1975).
Klein, E., Klein, G. & Levine, P. H. Cancer Res. 36, 724–727 (1976).
Ortaldo, J. R., Bonnard, G. D., Kind, P. D. & Herberman, R. B. J. Immun. 122, 1489–1494 (1979).
Seeley, J. K., Masucci, G., Poros, A., Klein, E. & Golub, S. H. J. Immun. 123, 1303–1311 (1979).
Viallat, J., Svedmyr, E., Steinitz, M. & Klein, G. Cell. Immun. 38, 68–75 (1978).
Jondal, M. & Targan, S. J. exp. Med. 147, 1621–1636 (1978).
Van Lambalgen, R., Farrant, J. & Bradley, B. A. J. immun. Meth. 27, 327–338 (1979).
Lydon, M. J., Keeler, K. D. & Thomas, D. B. J. cell. Physiol. 102, 175–181 (1980).
Luka, J., Siegert, W. & Klein, G. J. Virol. 22, 1–8 (1977).
Gerber, P., Nonoyama, M., Lucas, S., Perlin, E. & Goldstein, L. I. Lancet ii, 988–989 (1972).
Miller, G., Niederman, J. C. & Andrews, L-L. New Engl. J. Med. 288, 229–232 (1973).
Morgan, D. G., Niederman, J. C., Miller, G., Smith, H. W. & Dowaliby, J. M. Lancet ii, 1154–1157 (1979).
Crawford, D. H., Rickinson, A. B., Finerty, S. & Epstein, M. A. J. gen. Virol. 38, 449–460 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moss, D., Rickinson, A., Wallace, L. et al. Sequential appearance of Epstein–Barr virus nuclear and lymphocyte-detected membrane antigens in B cell transformation. Nature 291, 664–666 (1981). https://doi.org/10.1038/291664a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/291664a0
This article is cited by
-
The clinico-pathological expressions of Epstein-Barr virus infection in lymphoid tissues
Virchows Archiv B Cell Pathology Including Molecular Pathology (1987)
-
New HLA-A2 variants defined by monoclonal antibodies and cytotoxic T lymphocytes
Immunogenetics (1987)
-
Characterization of the HLA-A2.2 subtype: T cell evidence for further heterogeneity
Immunogenetics (1985)
-
Mutant HLA-A2 antigens as restricting elements for virus-specific cytotoxic T cells
Immunogenetics (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.