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Enhanced frequency of chromosome aberrations in lymphocytes of male compared with female muntjacs after X-ray irradiation in vitro

Nature volume 290, pages 604–607 (1981)Cite this article

Abstract

Recently, there has been considerable interest in the study of radiation-induced dicentrics and other chromosome aberrations in phytohaemagglutinin (PHA)-stimulated blood lymphocytes of various mammals, including man, with the aim of establishing a proper biological dosimetry for the assessment of genetic radiation hazards in human. These studies have revealed that the radiosensitivity of lymphocytes differs between species and even between individuals of the same species1–5, but the cause(s) of these variations still remains unclear. The life-shortening response to whole-body X-ray irradiation is influenced by both age and sex of the individuals6–9, but although age has been shown to have effects on chromosome aberration yields4,10–12 in vitro, the influence of sex on the sensitivity of lymphocyte chromosomes to radiation-induced damage has not been reported. It is generally thought that sex does not influence the aberration yield within the limitation of measurements used in such studies. However, we report here a study of X-ray induced chromosome aberration in lymphocytes of Indian muntjac, in which the yield of dicentrics was found to be consistently greater in male than in female lymphocytes.

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References

  1. Shankaranarayanan, K. Mutat. Res. 35, 371–386 (1976).

    Article  Google Scholar 

  2. Preston, R. J. & Brewen, J. G. in Mutagen Induced Chromosome Damage in Man. (eds Evans, H. J. & Lloyd, D. L. ) 33–40 (Edinburgh University Press, 1978).

    Google Scholar 

  3. Scott, D. & Lyons, C. Y. Nature 278, 756–758 (1978).

    Article  ADS  Google Scholar 

  4. Sasaki, M. S., Tonomura, A. & Matsubura, S. Mutat. Res. 10, 617–633 (1970).

    Article  CAS  Google Scholar 

  5. Bockhov, N. P. & Pilosov, R. A. Genetics 4, 144–152 (1968).

    Google Scholar 

  6. Holland, J. M. & Mitchell, T. J. Radiat. Res. 66, 363–372 (1976).

    Article  ADS  CAS  Google Scholar 

  7. Abrams, H. L. Proc. Soc. exp. Biol. Med. 76, 729–732 (1951).

    Article  CAS  Google Scholar 

  8. Lindop, P. J. & Rotblat, J. Br. J. Radial. 35, 23–31 (1962).

    Article  CAS  Google Scholar 

  9. Leonard, A., Maisin, J. R. & Deknidt, G. Strahlentherapie 137, 92–100 (1969).

    CAS  PubMed  Google Scholar 

  10. Sasaki, M. S. & Tonomura, A. Jap. J. hum. Genet. 14, 81–92 (1969).

    CAS  PubMed  Google Scholar 

  11. Evans, H. J. & Adams, A. in Advances in Radiation Research. Proc. 4th int. Congr. Radiat. Res. (eds Duplan, J. F. & Chapiro, A. ) (Gordon & Breach, New York, 1973).

    Google Scholar 

  12. Konopliannikova, O. A. Genetika 10, 111–119 (1966).

    Google Scholar 

  13. Wurster, D. H. & Benirschke, K. Science 168, 1364–1366 (1970).

    Article  ADS  CAS  Google Scholar 

  14. Sharma, T. Cytogenetics 11, 1–6 (1972).

    Article  CAS  Google Scholar 

  15. Sharma, T. & Das, B. C. Mutat. Res. (in the press).

  16. Perry, P. & Wolff, S. Nature 251, 156–158 (1974).

    Article  ADS  CAS  Google Scholar 

  17. Goto, K., Akematsu, T., Shimazu, H. & Sugiyama, T. Chromosoma 53, 223–230 (1975).

    Article  CAS  Google Scholar 

  18. Das, B. C. & Sharma, T. 3rd a. scient. Meet. of Environmental Mutagen Society of India, Ahmedabad, Abst. 8 (1977).

  19. Savage, J. R. K. Nature 278, 687 (1979).

    Article  ADS  CAS  Google Scholar 

  20. Bianchi, N. O., Bianchi, M. S. & Larramendy, M. Mutat. Res. 63, 317–324 (1979).

    Article  CAS  Google Scholar 

  21. Leonard, A. & Decat, G. Can. J. Genet. Cytol. 21, 473–478 (1979).

    Article  CAS  Google Scholar 

  22. Wolff, S., Rodin, B. & Cleaver, J. E. Nature 265, 347–348 (1977).

    Article  ADS  CAS  Google Scholar 

  23. Wolff, S. A. Rev. Genet. 11, 183–201 (1977).

    Article  CAS  Google Scholar 

  24. Bender, M. A. & Brewen, J. G. Mutat. Res. 8, 383–399 (1969).

    Article  CAS  Google Scholar 

  25. Steffen, J. & Michalowski, A. Mutat. Res. 17, 367–376 (1973).

    Article  CAS  Google Scholar 

  26. Savage, J. R. K. & Papworth, D. G. J. theor. Biol. 22, 493–514 (1969).

    Article  CAS  Google Scholar 

  27. Kucerova, M. Acta radiol. 6, 441–448 (1967).

    Article  Google Scholar 

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  1. Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India

    B. C. Das & T. Sharma

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  1. B. C. Das
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  2. T. Sharma
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Das, B., Sharma, T. Enhanced frequency of chromosome aberrations in lymphocytes of male compared with female muntjacs after X-ray irradiation in vitro. Nature 290, 604–607 (1981). https://doi.org/10.1038/290604a0

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