Abstract
The histocompatibility–Y (H–Y) antigen is a minor his to compatibility antigen which has been detected on cell surfaces from the heterogametic sexes of mammalian, bird, amphibian, teleost and invertebrate species1–3. H–Y is thought to be a male-determining substance in mammals because of its almost perfect correlation with maleness among a variety of mammalian species. To characterize the molecular determinant responsible for H–Y-specific serological activity, H–Y-positive immunoabsorbent cells were first subjected to various treatments which alter protein or carbohydrate structure and then tested for their ability to absorb H–Y antisera. We present here evidence that the serological determinant of H–Y antigen is carbohydrate.
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Shapiro, M., Erickson, R. Evidence that the serological determinant of H–Y antigen is carbohydrate. Nature 290, 503–505 (1981). https://doi.org/10.1038/290503a0
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DOI: https://doi.org/10.1038/290503a0
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