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Substrate-adhering lymphoid cells show impaired tumorigenicity and increased immunogenicity

Nature volume 290, pages 248–249 (1981)Cite this article

Abstract

Cell adhesiveness is fundamental to a variety of biological phenomena, including tumour development and metastasis1–4. Recently, Bubenik et al.5 have reported that in various malignant fibroblastoid cell lines those cells which demonstrated less adhesiveness were more tumorigenic. The relationship between cell adhesiveness, transformation and metastasis has been studied extensively in cells (fibroblastoid) grown as monolayers attached to their substratum and to each other4,6–9, but, to our knowledge, there has been no report describing this relationship in suspension-borne (lymphoid) cells that grow free of each other and their substratum. We report here that substrate-adhering variant cells, selected from the tumorigenic, suspension-growing S49 mouse lymphoma, have impaired tumorigenicity. Furthermore, the substrate-adhering cells also have increased immunogenicity, as their inoculation into mice protects the mice from subsequent challenges with parental, non-adherent tumorigenic S49 cells. These findings suggest a new approach for the selection of immunogenic cells from suspension-borne tumorigenic cell populations.

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Author notes

  1. Jacob Hochman

    Present address: Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland, 20205, USA

Authors and Affiliations

  1. Department of Zoology, The Hebrew University of Jerusalem, Jerusalem, Israel

    Jacob Hochman, Aviva Katz, Efrat Levy & Shmuela Eshel

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  1. Jacob Hochman
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  2. Aviva Katz
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  3. Efrat Levy
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  4. Shmuela Eshel
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Hochman, J., Katz, A., Levy, E. et al. Substrate-adhering lymphoid cells show impaired tumorigenicity and increased immunogenicity. Nature 290, 248–249 (1981). https://doi.org/10.1038/290248a0

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