Abstract
Two mutations in a mitochondrial structural gene, which cause leaky premature polypeptide chain termination and leaky growth, are +1 and −1 frameshifts in the same run of five T residues. The partial restoration of reading frame is probably due to ribosomal frameshifting at this site, and may be promoted by the unique structure of the yeast mitochondrial tRNAPhe (ref. 1).
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Fox, T., Weiss-Brummer, B. Leaky +1 and −1 frameshift mutations at the same site in a yeast mitochondrial gene. Nature 288, 60–63 (1980). https://doi.org/10.1038/288060a0
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DOI: https://doi.org/10.1038/288060a0
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