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A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events

Nature volume 286, pages 779783 (21 August 1980) | Download Citation

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Abstract

A mutant immunoglobulin gene has been formed by an abnormal (non V/J) recombination event such that abnormal RNA splicing is required to form a mutant light chain. The structure of the gene suggests that the small palindrome thought to be involved in V/J joining also provides the basis for this abnormal DNA recombination and that the absence of a J segment and RNA splice signal allows an abnormal RNA splicing reaction to occur.

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Affiliations

  1. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205

    • J. G. Seidman
    •  & Philip Leder

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https://doi.org/10.1038/286779a0

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