Letter | Published:

Elution of herpes simplex virus-specific cytotoxic antibodies from squamous cell carcinoma of uterine cervix

Nature volume 286, pages 613615 (07 August 1980) | Download Citation

Subjects

Abstract

There is evidence that carcinoma of the cervix uteri is associated with infection with herpes simplex virus type 2 (HSV-2), and although indirect evidence suggests an aetiological relationship1–6, this remains controversial7–9. One facet of the problem is that complement-dependent cytotoxic antibodies to HSV-2-infected cells have been undetectable or found only in low titre in sera from patients with progressive cervical cancer whereas higher titres have been found where cervical lesions are less advanced10,11. Indeed, cytotoxic antibody titres have been found to rise during the follow-up period after successful treatment11. Absorption of these antibodies by the tumour cells has been proposed as a possible reason for low HSV-2 cytolytic reactivity in patients with progressing cervical cancer10. This explanation assumes the presence of HSV-2-specific antigen(s) on the tumour cells. We now provide support for this assumption with evidence that absorbed HSV-2-specific antibodies can be eluted from cervical cancer tissue.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Am. J. Epidemiol. 91, 547–552 (1970).

  2. 2.

    et al. Cancer Res. 33, 1477–1482 (1973).

  3. 3.

    et al. Int. J. Cancer 33, 708–714 (1978).

  4. 4.

    et al. Proc. natn. Acad. Sci. U.S.A. 69, 3784–3789 (1972).

  5. 5.

    et al. Science 174, 704–707 (1971).

  6. 6.

    et al. Proc. Soc. exp. Biol. Med. 152, 343–347 (1976).

  7. 7.

    Biochim. biophys. Acta 417, 25–53 (1975).

  8. 8.

    & Prog. exp. Tumour Res. 21, 49–69 (1978).

  9. 9.

    & Prog. exp. Tumour Res. 21, 117–139 (1978).

  10. 10.

    Int. J. Cancer 20, 694–701 (1977).

  11. 11.

    et al. Am. J. Epidemiol. 100, 251–261 (1974).

  12. 12.

    & Cancer Res. 35, 58–62 (1975).

  13. 13.

    et al. J. biol Chem. 193, 265–275 (1951).

  14. 14.

    et al. Am. J. Epidemiol. 104, 181–191 (1976).

  15. 15.

    et al. Immunology 14, 181–196 (1968).

  16. 16.

    et al. J. gen. Virol. 45, 65–72 (1979).

  17. 17.

    et al. Science 178, 306–307 (1972).

  18. 18.

    Nature 204, 846–847 (1964).

  19. 19.

    Adv. Cancer Res. 25, 95–148 (1978).

  20. 20.

    et al. Clin. exp. Immun. 38, 77–82 (1979).

Download references

Author information

Affiliations

  1. Department of Microbiology, All India Institute of Medical Sciences, Ansari nagar, New Delhi-16, India

    • Pradeep Seth
    •  & N. Balachandran

Authors

  1. Search for Pradeep Seth in:

  2. Search for N. Balachandran in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/286613a0

Further reading Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.