Abstract
Insect juvenile hormones (JH) maintain larval characteristics of insects during growth and development. At high JH titres the larval hypodermis is programmed to secrete larval cuticle in the following moult1. Generally, the molecular events preceding the response of a target cell to a hormonal stimulus involve binding of the hormone to specific receptor molecules. There are little data available on the primary mechanism of action of JH at the molecular level. We have demonstrated the specific uptake and retention of JH-I in the cytosol of larval Drosophila hydei integument in vitro (G.K. and H.E., in preparation). We now report the discovery of high-affinity, high-specificity JH-binding principles that exhibit characteristic properties of hormone receptors, in the cytosol of early third instar D. hydei larval integument.
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Klages, G., Emmerich, H. & Peter, M. High-affinity binding sites for juvenile hormone I in the larval integument of Drosophila hydei. Nature 286, 282–285 (1980). https://doi.org/10.1038/286282a0
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DOI: https://doi.org/10.1038/286282a0
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