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Glucocorticoids increase osteoblast-like bone cell response to 1,25(OH)2D3

Nature volume 285, pages 254–257 (1980)Cite this article

Abstract

Recent reports indicate that some hormones may regulate the binding of, and subsequent response to, other hormones by their target tissue1–6. The adrenal glucocorticoids are prominent among these modulating hormones3–6. Glucocorticoids have been shown to enhance bone cell sensitivity to parathyroid hormone (PTH)6,7 in vitro and this in turn has permitted PTH-induced effects to be measured at physiological doses of PTH for the first time in isolated osteoblast-like (OB) and osteoclast-like (OC) cells. It is unknown whether these findings represent a specific interaction between glucocorticoids and PTH6 or indicate a general role for glucocorticoids in the development and/or maintenance of bone cell differentiation, of which hormonal responsiveness would be one expression. In the event of a general glucocorticoid effect on cell differentiation, increased responsiveness to other bone resorbing hormones should also be observed. We have therefore examined whether glucocorticoids enhance the sensivity of bone cells to a steroid hormone, 1,25 dihydroxycholecalciferol (1,25(OH)2D3), and we report here that they do.

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Authors and Affiliations

  1. Division of Metabolism, Endocrinology and Genetics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66103

    Glenda L. Wong, Barbara P. Lukert & John S. Adams

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  1. Glenda L. Wong
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  2. Barbara P. Lukert
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  3. John S. Adams
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Wong, G., Lukert, B. & Adams, J. Glucocorticoids increase osteoblast-like bone cell response to 1,25(OH)2D3. Nature 285, 254–257 (1980). https://doi.org/10.1038/285254a0

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