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Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae

Abstract

Unequal sister chromatid exchanges occur at the ribosomal DNA locus of yeast during mitotic growth. The frequency of unequal crossing over, as measured by the deletion or duplication of an inserted genetic marker (LEU2), is sufficient to maintain the sequence homogeneity of the rDNA repeat units.

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References

  1. Bell, G. I. et al. J. biol Chem. 252, 8118–9125 (1977).

    CAS  PubMed  Google Scholar 

  2. Cramer, J. M., Farrelly, F. W., Barnitz, J. T. & Rownd, R. M. Molec. gen. Genet. 151, 229–244 (1977).

    Article  CAS  Google Scholar 

  3. Wellauer, P. K. & Dawid, I. B. Cell 10, 193–212 (1977).

    Article  CAS  Google Scholar 

  4. Glover, D. M. & Hogness, D. S. Cell 10, 167–176 (1977).

    Article  CAS  Google Scholar 

  5. Wellauer, P. K., Dawid, L. B., Brown, D. D. & Reeder, R. H. J. molec. Biol. 105, 461–486 (1976).

    Article  CAS  Google Scholar 

  6. Carroll, D. & Brown, D. D. Cell 7, 477–486 (1976).

    Article  CAS  Google Scholar 

  7. Manning, R. F., Samols, D. R. & Gage, L. P. Gene 4, 153–166 (1978).

    Article  CAS  Google Scholar 

  8. Wilson, F. E., Blin, N. & Stafford, D. W. Chromosoma 65, 373–381 (1978).

    Article  CAS  Google Scholar 

  9. Schweizer, F., MacKechnie, C. & Halvorson, H. W. J. molec Biol. 40, 261–277 (1969).

    Article  CAS  Google Scholar 

  10. Rubin, G. M. & Sulston, J. E. J. molec. Biol. 79, 521–536 (1973).

    Article  CAS  Google Scholar 

  11. Udem, S. A. & Warner, J. R. J. molec. Biol. 65, 227–242 (1972).

    Article  CAS  Google Scholar 

  12. Nath, K. & Bollon, A. P. Molec. gen. Genet. 160, 235–245 (1978).

    Article  CAS  Google Scholar 

  13. Cohen, A., Ram, D., Halvorson, H. O. & Wensink, P. C. Gene 3, 135–147 (1978).

    Article  CAS  Google Scholar 

  14. Schaffner, W., Gross, K., Telford, J. & Birnsteil, M. Cell 8, 471–478 (1976).

    Article  CAS  Google Scholar 

  15. Cohn, R. H., Lowry, J. C. & Kedes, L. H. Cell 9, 147–161 (1976).

    Article  CAS  Google Scholar 

  16. Lifton, R. P., Goldberg, M. L., Karp, R. W. & Hogness, D. S. Cold Spring Harb. Symp. quant. Biol. 17, 1047–1052 (1977).

    Google Scholar 

  17. Crawford, R. V., Krieg, P., Harvey, R. P., Hewish, D. A. & Wells, J. R. E. Nature 279, 132–136 (1979).

    Article  ADS  CAS  Google Scholar 

  18. Botchan, M. R. Nature 251, 288–292 (1974).

    Article  ADS  CAS  Google Scholar 

  19. Cooke, H. J. & McKay, R. D. G. Cell 13, 453–460 (1978).

    Article  CAS  Google Scholar 

  20. Callan, H. G. J. Cell Sci. 2, 1–8. (1967).

    CAS  Google Scholar 

  21. Edelman, G. M. & Gally, J. A. J. Cell Sci. 2, 962–972 (1970).

    Google Scholar 

  22. Buongiorno-Nardelli, M., Amaldi, F. & Lava-Sanchez, P. A. Nature new Biol. 238, 134–137 (1972).

    Article  CAS  Google Scholar 

  23. Smith, G. P. Cold Spring Harb. Symp. quant. Biol. 38, 507–513. (1974).

    Article  CAS  Google Scholar 

  24. Tartof, K. D. Cold. Spring Harb. Symp. quant. Biol. 38, 491–500. (1974).

    Article  CAS  Google Scholar 

  25. Szostak, J. W. & Wu, R. Plasmid 2, 536–554. (1979).

    Article  CAS  Google Scholar 

  26. Bolivar, F. et al. Gene 2, 95–113 (1977).

    Article  CAS  Google Scholar 

  27. Ratzkin, B. & Carbon, J. Proc. natn. Acad. Sci. U.S.A. 74, 487–491 (1977).

    Article  ADS  CAS  Google Scholar 

  28. Hicks, J. B. & Fink, D. R. Nature 269, 265–267 (1977).

    Article  ADS  CAS  Google Scholar 

  29. Hinnen, A., Hicks, J. B. & Fink, G. R. Proc. natn. Acad. Sci. U.S.A. 75, 1929–1933 (1978).

    Article  ADS  CAS  Google Scholar 

  30. Ilgen, C., Farabaugh, P. V., Hinnen, A., Walsh, J. M. & Fink, G. R. Genetic Engineering Vol. 1 (eds Setlow, J. K. & Hollaender, A.) 117–132 (Plenum, New York, 1979).

    Book  Google Scholar 

  31. Szostak, J. W. & Wu, R. (in preparation).

  32. Luria, S. E. & Delbruck, M. Genetics 28, 491–504 (1973).

    Google Scholar 

  33. Cryer, D. R., Eccleshall, R. & Marmur, J. Meth. Cell Biol.

  34. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  35. Ohta, T. Nature 263, 74–76 (1976).

    Article  ADS  CAS  Google Scholar 

  36. Ritossa, F. M. Nature new Biol. 240, 109–111 (1972).

    Article  CAS  Google Scholar 

  37. Cramer, J. H., Bhargava, M. M. & Halvorson, H. D. J. molec. Biol. 71, 11–20 (1972).

    Article  CAS  Google Scholar 

  38. Taylor, J. H., Woods, P. S. & Hughes, W.L. Proc. natn. Acad. Sci. U.S.A. 43, 122–127 (1957).

    Article  ADS  CAS  Google Scholar 

  39. Yamamoto, M. & Miklos, G. L. G. Chromsoma 66, 71–98 (1978).

    Article  CAS  Google Scholar 

  40. Peterson, H. & Laughnan, J. R. Genetics 50, 126–133 (1963).

    CAS  Google Scholar 

  41. Petes, T. D. & Botstein, D. Proc. natn. Acad. Sci. U.S.A. 74, 5091–5095 (1977).

    Article  ADS  CAS  Google Scholar 

  42. Struhl, K., Stinchomb, D. T., Scherer, S. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 76, 1035–1039 (1979).

    Article  ADS  CAS  Google Scholar 

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Szostak, J., Wu, R. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature 284, 426–430 (1980). https://doi.org/10.1038/284426a0

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