Abstract
Unequal sister chromatid exchanges occur at the ribosomal DNA locus of yeast during mitotic growth. The frequency of unequal crossing over, as measured by the deletion or duplication of an inserted genetic marker (LEU2), is sufficient to maintain the sequence homogeneity of the rDNA repeat units.
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References
Bell, G. I. et al. J. biol Chem. 252, 8118–9125 (1977).
Cramer, J. M., Farrelly, F. W., Barnitz, J. T. & Rownd, R. M. Molec. gen. Genet. 151, 229–244 (1977).
Wellauer, P. K. & Dawid, I. B. Cell 10, 193–212 (1977).
Glover, D. M. & Hogness, D. S. Cell 10, 167–176 (1977).
Wellauer, P. K., Dawid, L. B., Brown, D. D. & Reeder, R. H. J. molec. Biol. 105, 461–486 (1976).
Carroll, D. & Brown, D. D. Cell 7, 477–486 (1976).
Manning, R. F., Samols, D. R. & Gage, L. P. Gene 4, 153–166 (1978).
Wilson, F. E., Blin, N. & Stafford, D. W. Chromosoma 65, 373–381 (1978).
Schweizer, F., MacKechnie, C. & Halvorson, H. W. J. molec Biol. 40, 261–277 (1969).
Rubin, G. M. & Sulston, J. E. J. molec. Biol. 79, 521–536 (1973).
Udem, S. A. & Warner, J. R. J. molec. Biol. 65, 227–242 (1972).
Nath, K. & Bollon, A. P. Molec. gen. Genet. 160, 235–245 (1978).
Cohen, A., Ram, D., Halvorson, H. O. & Wensink, P. C. Gene 3, 135–147 (1978).
Schaffner, W., Gross, K., Telford, J. & Birnsteil, M. Cell 8, 471–478 (1976).
Cohn, R. H., Lowry, J. C. & Kedes, L. H. Cell 9, 147–161 (1976).
Lifton, R. P., Goldberg, M. L., Karp, R. W. & Hogness, D. S. Cold Spring Harb. Symp. quant. Biol. 17, 1047–1052 (1977).
Crawford, R. V., Krieg, P., Harvey, R. P., Hewish, D. A. & Wells, J. R. E. Nature 279, 132–136 (1979).
Botchan, M. R. Nature 251, 288–292 (1974).
Cooke, H. J. & McKay, R. D. G. Cell 13, 453–460 (1978).
Callan, H. G. J. Cell Sci. 2, 1–8. (1967).
Edelman, G. M. & Gally, J. A. J. Cell Sci. 2, 962–972 (1970).
Buongiorno-Nardelli, M., Amaldi, F. & Lava-Sanchez, P. A. Nature new Biol. 238, 134–137 (1972).
Smith, G. P. Cold Spring Harb. Symp. quant. Biol. 38, 507–513. (1974).
Tartof, K. D. Cold. Spring Harb. Symp. quant. Biol. 38, 491–500. (1974).
Szostak, J. W. & Wu, R. Plasmid 2, 536–554. (1979).
Bolivar, F. et al. Gene 2, 95–113 (1977).
Ratzkin, B. & Carbon, J. Proc. natn. Acad. Sci. U.S.A. 74, 487–491 (1977).
Hicks, J. B. & Fink, D. R. Nature 269, 265–267 (1977).
Hinnen, A., Hicks, J. B. & Fink, G. R. Proc. natn. Acad. Sci. U.S.A. 75, 1929–1933 (1978).
Ilgen, C., Farabaugh, P. V., Hinnen, A., Walsh, J. M. & Fink, G. R. Genetic Engineering Vol. 1 (eds Setlow, J. K. & Hollaender, A.) 117–132 (Plenum, New York, 1979).
Szostak, J. W. & Wu, R. (in preparation).
Luria, S. E. & Delbruck, M. Genetics 28, 491–504 (1973).
Cryer, D. R., Eccleshall, R. & Marmur, J. Meth. Cell Biol.
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Ohta, T. Nature 263, 74–76 (1976).
Ritossa, F. M. Nature new Biol. 240, 109–111 (1972).
Cramer, J. H., Bhargava, M. M. & Halvorson, H. D. J. molec. Biol. 71, 11–20 (1972).
Taylor, J. H., Woods, P. S. & Hughes, W.L. Proc. natn. Acad. Sci. U.S.A. 43, 122–127 (1957).
Yamamoto, M. & Miklos, G. L. G. Chromsoma 66, 71–98 (1978).
Peterson, H. & Laughnan, J. R. Genetics 50, 126–133 (1963).
Petes, T. D. & Botstein, D. Proc. natn. Acad. Sci. U.S.A. 74, 5091–5095 (1977).
Struhl, K., Stinchomb, D. T., Scherer, S. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 76, 1035–1039 (1979).
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Szostak, J., Wu, R. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature 284, 426–430 (1980). https://doi.org/10.1038/284426a0
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DOI: https://doi.org/10.1038/284426a0
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