Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Tumour promoter uncouples β-adrenergic receptor from adenyl cyclase in mouse epidermis

Nature volume 284, pages 171–173 (1980)Cite this article

Abstract

Alterations in β-adrenergic receptor number and function and in the hormonal responsiveness of adenylate cyclase have been observed in transformed cells1–3, and tumours4,5. Phorbol myristate acetate (PMA), a potent tumour promoter in mouse skin, induces a dramatic loss of epidermal responsiveness to catecholamines in vivo6,8, although basal levels of cyclic AMP are not affected7–9. In other work we have shown that PMA treatment does not alter the number or affinity of epidermal β-receptors, although accumulation of cyclic AMP in response to isoprenaline injection is sharply inhibited10. Evidence is presented here that PMA exerts this effect by uncoupling epidermal β-receptors from adenylate cyclase.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Sheppard, J. R., Gormus, R. & Moldow, C. F. Nature 269, 693–695 (1977).

    Article  ADS  CAS  Google Scholar 

  2. Sheppard, J. R. Proc. natn. Acad. Sci. U.S.A. 74, 1091–1094 (1977).

    Article  ADS  CAS  Google Scholar 

  3. Makarski, J. S. & Niles, R. M. Expl Cell Res. 114, 191–195 (1978).

    Article  CAS  Google Scholar 

  4. Allen, D. O., Munshower, J., Morris, H. P. & Weber, G. Cancer Res. 31, 557–560 (1971).

    CAS  PubMed  Google Scholar 

  5. Boyd, H., Louis, C. J. & Martin, T. J. Cancer Res. 34, 1720–1725 (1974).

    CAS  PubMed  Google Scholar 

  6. Grimm, W. & Marks, F. Cancer Res. 34, 3128–3134 (1974).

    CAS  PubMed  Google Scholar 

  7. Mufson, R. A., Simsiman, R. C. & Boutwell, R. K. Cancer Res. 37, 665–669 (1977).

    CAS  PubMed  Google Scholar 

  8. Belman, S., Troll, W. & Garte, S. J. Cancer Res. 38, 2978–2982 (1978).

    CAS  PubMed  Google Scholar 

  9. Garte, S. J. & Belman, S. Biochem. Biophys. Res. Commun. 84, 489–494 (1978).

    Article  CAS  Google Scholar 

  10. Belman, S. & Garte, S. J. Cancer Res. 40, 240–244 (1980).

    CAS  PubMed  Google Scholar 

  11. Maguire, M. E., Ross, E. M. & Oilman, A. G. Adv. Cyclic Nudeotide Res. 8, 1–83 (1977).

    CAS  Google Scholar 

  12. Lefkowitz, R. J. & Williams, L. T. Adv. Cyclic Nudeotide Res. 9, 1–18 (1978).

    CAS  Google Scholar 

  13. Ross, E. M., Maguire, M. E., Surgill, T. W., Biltonen, R. L. & Oilman, A. G. J. biol. Chem. 252, 5761–5775 (1977).

    CAS  PubMed  Google Scholar 

  14. Lefkowitz, R. J., Mukherjee, C., Coverstone, M. & Caron, M. G. Biochem. biophys. Res. Commun. 60, 703–709 (1974).

    Article  CAS  Google Scholar 

  15. Limbird, L. E. & Lefkowitz, R. J. Molec. Pharmac. 12, 559–567 (1976).

    CAS  Google Scholar 

  16. Puchwein, G., Pfeuffer, T. & Helmreich, E. J. M. J. biol. Chem. 249, 3232–3240 (1974).

    CAS  PubMed  Google Scholar 

  17. Haga, T., Ross, E. M., Anderson, H. J. & Oilman, A. G. Proc. natn. Acad. Sci. U.S.A. 74, 2016–2020 (1977).

    Article  ADS  CAS  Google Scholar 

  18. Weinstein, I. B., Wigler, M. & Pietropaolo, C. in Origins of Human Cancer Vol. 4 (eds Hiatt, H. H., Watson, J. D. & Winsten, J. A.) 751–771 (Cold Spring Harbor Laboratory, New York, 1977).

    Google Scholar 

  19. Blumberg, P. M., Driedger, P. E. & Rossow, P. W. Nature 264, 446–447 (1976).

    Article  ADS  CAS  Google Scholar 

  20. Sivak, A., Mossman, B. T. & Van Duuren, B. L. Biochem. biophys. Res. Commun. 46, 605–609 (1972).

    Article  CAS  Google Scholar 

  21. Lee, L. S. & Weinstein, I. B. Science 202, 313–315 (1978).

    Article  ADS  CAS  Google Scholar 

  22. Rimon, G., Hanski, E., Braun, S. & Levitzki, A. Nature 276, 394–396 (1978).

    Article  ADS  CAS  Google Scholar 

  23. Switzer, B. R. & Summer, G. K. Clin. chim. Acta 32, 203–206 (1971).

    Article  CAS  Google Scholar 

  24. Cornish-Bowden, A. & Koshland, D. E. J. molec. Biol. 95, 201–212 (1975).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Environmental Medicine, New York University Medical Center, New York, New York, 10016

    S. J. Garte & S. Belman

Authors
  1. S. J. Garte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Belman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Garte, S., Belman, S. Tumour promoter uncouples β-adrenergic receptor from adenyl cyclase in mouse epidermis. Nature 284, 171–173 (1980). https://doi.org/10.1038/284171a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/284171a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing