Review Article | Published:

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

Abstract

Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Rodbell, M. in Molecular Biology and Pharmacology of Cyclic Nucleotides (eds Folco, G. & Paoletti, R.) 1–12 (Elsevier, Amsterdam, 1978).

  2. 2

    Rodbell, M., Birnbaumer, L., Pohl, S. L. & Krans, H. M. J. J. biol. Chem. 246, 1877–1882 (1971).

  3. 3

    Rodbell, M. et al. Adv. Cyclic Nucleotide Res. 5, 3–29 (1975).

  4. 4

    Perkins, J. P. Adv. Cyclic Nucleotide Res. 3, 1–64 (1973).

  5. 5

    Pfeuffer, T. J. biol. Chem. 252, 7224–7234 (1977).

  6. 6

    Pfeuffer, T. FEBS Lett. 101, 85–89 (1979).

  7. 7

    Finkelstein, R. A. Crit. Rev. Microbiol. 2, 553–623 (1973).

  8. 8

    Gill, D. M. Adv. Cyclic Nucleotide Res. 8, 85–118 (1977).

  9. 9

    Johnson, G. L. & Bourne, H. R. Biochem. biophys. Res. Commun. 78, 792–798 (1977).

  10. 10

    Fischer, J. & Sharp, G. W. G. Biochem. J. 176, 505–510 (1978).

  11. 11

    Cassel, D. & Selinger, Z. Proc. natn. Acad. Sci. U.S.A. 74, 3307–3311 (1977).

  12. 12

    Levinson, S. L. & Blume, A. J. J. biol. Chem. 252, 3766–3774 (1977).

  13. 13

    Lin, M. C., Welton, A. F. & Berman, M. F. J. Cyclic Nucleotide Res. 4, 159–168 (1978).

  14. 14

    Cassel, D. & Selinger, Z. Biochim. biophys. Acta 452, 538–551 (1978).

  15. 15

    Gill, D. M. & Meren, R. Proc. natn. Acad. Sci. U.S.A. 75, 3050–3054 (1978).

  16. 16

    Cassel, D. & Pfeuffer, T. Proc. natn. Acad. Sci. U.S.A. 75, 2669–2673 (1978).

  17. 17

    Johnson, G. L., Kaslow, H. R. & Bourne, H. R. Proc. natn. Acad. Sci. U.S.A. 75, 3113–3117 (1978).

  18. 18

    Johnson, G. L., Kaslow, H. R. & Bourne, H. R. J. biol. Chem. 253, 7120–7123 (1978).

  19. 19

    Ross, E. M., Hewlett, A. C., Ferguson, K. M. & Gilman, A. G. J. biol. Chem. 253, 6401–6412 (1978).

  20. 20

    Howlett, A. C., Sternweiss, P. C., Macik, B. A., Van Arsdale, P.M. & Gilman, A. G. J. biol. Chem. 254, 2287–2295 (1979).

  21. 21

    Londos, C., Lad, P. M., Nielsen, T. B. & Rodbell, M. J. supramolec. Struct. 10, 1031–1037 (1979).

  22. 22

    Nielsen, T., Lad, P. M., Preston, M.S. & Rodbell, M. Biochim. biophys. Acta (in the press).

  23. 23

    Rodbell, M., Krans, H. M. J., Pohl, S. L. & Birnbaumer, L. J. biol. Chem. 246, 1872–1876 (1971).

  24. 24

    Rodbell, M., Lin, M. C. & Salomon, Y. J. biol. Chem. 249, 59–65 (1974).

  25. 25

    Lin, M. C., Nicosia, S., Lad, P. M. & Rodbell, M. J. biol. Chem. 252, 2790–2792 (1977).

  26. 26

    Sonne, O., Berg, T. & Christoffersen, T. J. biol. Chem. 253, 3203–3210 (1978).

  27. 27

    Lad, P. M., Welton, A. F. & Rodbell, M. J. biol. Chem. 252, 5942–5946 (1977).

  28. 28

    Maguire, M. E., Van Arsdale, P. M. & Gilman, A. G. Molec. Pharmac. 12, 335–339 (1976).

  29. 29

    Ross, E. M., Maguire, M. E., Sturgill, T. W., Biltonen, R. L. & Gilman, A. G. J. biol. Chem. 252, 5761–5775 (1977).

  30. 30

    Williams, L. T. & Lefkowitz, R. J. J. biol. Chem. 252, 7207–7213 (1977).

  31. 31

    Lefkowitz, R. J. & Williams, L. T. Adv. Cyclic nucleotide Res. 9, 1–17 (1978).

  32. 32

    Sternweiss, P. C. & Gilman, A. G. J. biol. Chem. 254, 3333–3340 (1979).

  33. 33

    Welton, A. F. et al. J. biol. Chem. 252, 5947–5950 (1977).

  34. 34

    Limbird, L. E. & Lefkowitz, R. J. Proc. natn. Acad. Sci. U.S.A. 75, 228–232 (1978).

  35. 35

    Maguire, M. E., Ross, E. M. & Gilman, A. G. Adv. Cyclic Nucleotide Res. 8, 1–83 (1977).

  36. 36

    Iyengar, R. & Birnbaumer, L. Proc. natn. Acad. Sci. U.S.A. 76, 3189–3193 (1979).

  37. 37

    Iyengar, R., Swartz, T. L. & Birnbaumer, L. J. biol. Chem. 254, 1119–1123 (1979).

  38. 38

    Cassel, D. & Selinger, Z. Proc. natn. Acad. Sci. U.S.A. 75, 4155–4159 (1978).

  39. 39

    Lad, P. M., Nielsen, T., Preston, M. S. & Rodbell, M. J. biol. Chem. (in the press).

  40. 40

    Catt, K. J., Harwood, J. P., Aquilera, G. & Dufau, M. L. Nature 280, 109–116 (1979).

  41. 41

    Goldstein, J. L., Anderson, R. G. W. & Brown, M. S. Nature 279, 679–685 (1979).

  42. 42

    Cryer, P. E., Jarett, L. & Kipnis, D. Biochim. biophys. Acta 177, 586–590 (1969).

  43. 43

    Harwood, J. P., Low, H. & Rodbell, M. J. biol. Chem. 248, 6239–6245 (1973).

  44. 44

    Rodbell, M. J. biol. Chem. 250, 5826–5834 (1975).

  45. 45

    Pairault, J. Eur. J. Biochem. 62, 323–334 (1976).

  46. 46

    Ebert, R. & Schwabe, U. Naunyn-Schmiedebergs Archs Pharmak. 286, 297–313 (1974).

  47. 47

    Yamamura, H., Lad, P. M. & Rodbell, M. J. biol. Chem. 252, 7964–7966 (1977).

  48. 48

    Londos, C., Cooper, D. M. F., Schlegel, W. & Rodbell, M. Proc. natn. Acad. Sci. U.S.A. 75, 5362–5366 (1978).

  49. 49

    Cooper, D. M. F., Schlegel, W., Lin, M. C. & Rodbell, M. J. biol. Chem. 254, 8927–8931 (1979).

  50. 50

    Londos, C. & Wolff, J. Proc. natn. Acad. Sci. U.S.A. 74, 5482–5486 (1977).

  51. 51

    Sabol, S. L. & Nirenberg, M. J. biol. Chem. 254, 1913–1920 (1979).

  52. 52

    Blume, A. J., Lichtshtein, D. & Boone, G. Proc. natn. Acad. Sci. U.S.A. 76, 5626–5630 (1979).

  53. 53

    DeCamilli, P., Macconi, D. & Spada, A. Nature 278, 252–254 (1979).

  54. 54

    Jacobs, K. H. in Molecular Biology and Pharmacology of Cyclic Nucleotides (eds Folco, G. & Paoletti, R.) 265–278 (Elsevier, Amsterdam, 1978).

  55. 55

    Kempner, E. S. & Schlegel, W. Analyt. Biochem. 92, 2–10 (1979).

  56. 56

    Schlegel, W., Kempner, E. S. & Rodbell, M. J. biol. Chem. 254, 5168–5176 (1979).

  57. 57

    Brown, E. M., Fedak, S. A., Woodward, C. J., Aurbach, G. D. & Rodbard, D. J. biol. Chem. 251, 1239–1246 (1976).

  58. 58

    Nimmo, H. G. & Cohen, P. Adv. Cyclic Nucleotide Res. 8, 145–266 (1977).

  59. 59

    Lin, M. C., Lin, C-S & Whitlock, J. P. Jr J. biol. Chem. 254, 4684–4688 (1979).

  60. 60

    Bergman, R. N. & Hechter, O. J. biol. Chem. 253, 3238–3250 (1978).

  61. 61

    Tolkovsky, A. M. & Levitzki, A. Biochemistry 17, 3795–3810 (1978).

  62. 62

    Jacobs, S. & Cuatrecasas, P. Biochim. biophys. Acta 433, 482–495 (1976).

  63. 63

    Hechter, O., Terana, S., Nakahara, T., Fluoret, G. & Bergman, R. N. J. biol. Chem. 253, 3219–3229 (1978).

  64. 64

    Jard, S., Roy, C., Barth, T., Rajerson, R. & Bockaert, J. Adv. Cyclic Nucleotide Res. 5, 31–52 (1975).

  65. 65

    Brostrom, C. O., Huang, Y., Breckenridge, B. McL. & Wolff, D. J. Proc. natn. Acad. Sci. U.S.A. 72, 64–68 (1975).

  66. 66

    Moss, J. & Vaughan, M. Proc. natn. Acad. Sci. U.S.A. 74, 4396–4400 (1977).

  67. 67

    Pecker, F. & Hanoune, J. J. biol. Chem. 252, 2784–2786 (1977).

  68. 68

    Egan, J. J., Majeska, R. J. & Rodan, G. A. Biochem. biophys. Res. Commun. 80, 176–182 (1978).

  69. 69

    Katz, M. S., Kelly, T. M., Pineyro, M. A. & Gregerman, R. I. J. Cyclic Nucleotide Res. 5, 389–407 (1978).

  70. 70

    Edelman, G. M. Science 197, 218–226 (1976).

  71. 71

    Insel, P. A. & Kennedy, M. J. Nature 273, 471–472 (1978).

  72. 72

    Rudolf, S. A., Greengard, P. & Malawista, S. E. Proc. natn. Acad. Sci. U.S.A. 74, 3404–3408 (1977).

  73. 73

    Cassel, D., Levkovitz, H. & Selinger, Z. J. Cyclic Nucleotide Res. 3, 393–406 (1977).

  74. 74

    Cassel, D. & Selinger, Z. Biochem. biophys. Res. Commun. 77, 868–873 (1977).

  75. 75

    Rendell, M., Rodbell, M. & Berman, M. J. biol. Chem. 252, 7909–7912 (1977).

  76. 76

    Salomon, Y., Lin, M. C., Londos, C., Rendell, M. & Rodbell, M. J. biol. Chem. 250, 4239–4245 (1975).

  77. 77

    Harwood, J. P., Low, H. & Rodbell, M. J. biol. Chem. 248, 6239–6245 (1973).

  78. 78

    Eckstein, F., Cassel, D., Levkovitz, H., Lowe, M. & Selinger, Z. J. biol. Chem. 254, 9829–9834 (1979).

  79. 79

    Cassel, D., Eckstein, F., Lowe, M. & Selinger, Z. J. biol. Chem. 254, 9835–9838 (1979).

  80. 80

    Rubalcava, B. & Rodbell, M. J. biol. Chem. 248, 3831–3839 (1973).

  81. 81

    Lad, P. M., Preston, S., Welton, A. F., Nielsen, T. B. & Rodbell, M. Biochim. biophys. Acta 551, 368–391 (1979).

  82. 82

    Welton, A. F. et al. Biochim. biophys. Acta 522, 625–639 (1978).

  83. 83

    Blackmore, P. F., Brumby, F. T., Marks, J. L. & Exton, J. H. J. biol. Chem. 253, 4851–4858 (1978).

  84. 84

    Glossman, H., Baukal, A. & Catt, K. J. J. biol. Chem. 249, 664–666 (1974).

  85. 85

    Walaas, O., Walaas, E., Lystad, E., Alertsen, A. R. & Horn, R. S. Molec. cell. Endocr. 16, 45–55 (1979).

  86. 86

    Chan, T. M. & Exton, J. H. J. biol. Chem. 252, 8645–8651 (1977).

  87. 87

    Kebabian, J. W. & Caln, D. B. Nature 277, 93–96 (1979).

  88. 88

    Kebabian, J. W., Petzold, G. L. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 69, 2145–2149 (1972).

  89. 89

    Spano, P. F., Govoni, S. & Trabucchi, M. Adv. Biochem. Psychopharmac. 19, 155–166 (1977).

  90. 90

    VanInwegen, R. G., Strada, S. J. & Robison, G. A. Life Sci. 16, 1875–1876 (1975).

  91. 91

    Puri, S. K., Cochin, J. & Volicer, L. Life Sci. 16, 759–768 (1975).

  92. 92

    Clouet, D. H. & Iwatsubo, H. Life Sci. 17, 35–40 (1975).

  93. 93

    Jard, S. & Bockaert, J. Physiol. Rev. 55, 489–536 (1975).

  94. 94

    Kirk, C. S. & Hems, D. A. FEBS Lett. 47, 128–131 (1974).

  95. 95

    Macdermot, J. et al. Proc. natn. Acad. Sci. U.S.A. 76, 1135–1139 (1979).

  96. 96

    Gardner, J. D. A. Rev. Physiol. 41, 55–66 (1979).

  97. 97

    Hirata, F., Strittmatter, W. J. & Axelrod, J. Proc. natn. Acad. Sci. U.S.A. 76, 368–372 (1979).

  98. 98

    Moore, W. V. & Wolff, J. J. biol. Chem. 248, 5705–5711 (1973).

  99. 99

    Lefkowitz, R. J., Mullikin, D., Wood, C. L., Gorder, T. B. & Mukherjee, C. J. biol. Chem. 252, 5295–5303 (1977).

  100. 100

    Zahniser, N. R. & Molinoff, P. B. Nature 275, 453–454 (1978).

  101. 101

    Creese, I., Usdin, T. & Snyder, S. H. Nature 278, 577–578 (1978).

  102. 102

    Watanabe, A. M. et al. J. biol. Chem. 253, 4833–4836 (1978).

  103. 103

    Berrie, C. P., Birdsall, N. J. M., Burgen, A. S. V. & Hulme, S. C. Biochem. biophys. Res. Commun. 87, 1000–1005 (1979).

  104. 104

    Pert, C. B. & Taylor, D. in Endogenous and Exogenous Opiate Agonists and Antagonists (ed. Way, E. L.) (Pergamon, Oxford, in the press).

  105. 105

    Blume, A. J., Boone, G. & Lichtshtein, D. in Modulators, Mediators, and Specifiers in Brain Function (eds Erlich, Y. H., Volavka, J., Davis, L. F. & Brunngreben, E.) 163–173 (Plenum, New York, 1979).

  106. 106

    U'Prichard, D. C. & Snyder, S. H. J. biol. Chem. 253, 3444–3452 (1978).

  107. 107

    Glossman, H. & Presek, P. Naunyn-Schmiedebergs Archs Pharmak. 306, 67–73 (1979).

  108. 108

    Childers, S. R. & Snyder, S. H. Life Sci. 23, 759–762 (1978).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.