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Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

Abstract

Until now the inierfer on-mediated 2′–5′ adenine oligonucleotide inhibitors (2–5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.

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Williams, B., Golgher, R., Brown, R. et al. Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells. Nature 282, 582–586 (1979). https://doi.org/10.1038/282582a0

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