Abstract
Data are presented which suggest that there are unbound receptors for oestrogen in nuclei of the smooth muscle cells of the myometrium. A new model for the distribution of unbound receptors is proposed in which unbound receptor is in equilibrium, partitioned between nucleus and cytoplasm according to the free water content of these intracellular compartments.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gorski, J., Toft, D., Shyamata, G., Smith, D. & Notides, A. Rec. Prog. Horm. Res. 24, 45–80 (1968).
Jensen, E. V. & DeSombre, E. R. Science 182, 126–134 (1973).
O'Malley, B. W. & Means, A. R. Science 183, 610–620 (1974).
Sheridan, P. J. Life Sci. 17, 497–502 (1975).
Alberga, A., Massol, A., Raynaud, J. P. & Baulieu, E. E. Biochemistry 10, 3835–3841 (1971).
Jackson, V. & Chalkley, R. J. biol. Chem. 249, 1615–1626 (1974).
Zava, D. T. & McGuire, W. L. J. biol. Chem. 252, 3703–2708 (1977).
Siiteri, P. K. et al. Adv. exp. Med. Biol. 36, 97–112 (1973).
Linkie, D. M. Endocrinology 101, 1862–1870 (1977).
Yamamoto, K. R. & Alberts, B. Proc. natn. Acad. Sci. U.S.A. 69, 2105–2109 (1972).
Jensen, E. V. et al. Proc. natn. Acad. Sci. U.S.A. 59, 632–638 (1968).
Stumpf, W. E. Acta endocr., Kbh. Suppl. 153, 205–221 (1971).
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. J. biol. Chem. 193, 265–275 (1951).
Williams, D. & Gorski, J. Biochemistry 13, 5537–5542 (1974).
Williams, D. & Gorski, J. Biochem. biophys. Res. Commun. 45, 258–264 (1971).
Horowitz, S. B. & Moore, L. C. J. Cell Biol. 60, 405–415 (1974).
Gorski, J. & Gannon, F. A. Rev. Physiol. 38, 425–450 (1976).
Williams, D. & Gorski, J. Proc. natn. Acad. Sci. U.S.A. 69, 3444–3468 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sheridan, P., Buchanan, J., Anselmo, V. et al. Equilibrium: the intracellular distribution of steroid receptors. Nature 282, 579–582 (1979). https://doi.org/10.1038/282579a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/282579a0
This article is cited by
-
The estrogen receptor: two or more molecules, multiple variants, diverse localizations, signaling and functions. Are we undergoing a paradigm-shift as regards their significance in breast cancer?
Hormones (2013)
-
Distribution of estrogen and progesterone receptors in healthy tissue adjacent to breast lesions at various stages — Immunohistochemical study of 107 cases
Breast Cancer Research and Treatment (1990)
-
The effect of homogenization temperature upon the apparent cellular compartmentalization of unoccupied estrogen receptor
Experientia (1989)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.