Abstract
THE super-luteinising hormone-releasing factors (super-LRFs) are a group of synthetic analogues at least 100 times more potent than the native peptide in vitro and in vivo1. Several laboratories have demonstrated inhibitory effects of super-LRFs on ovulation, egg implantation, pregnancy, testicular weight and spermatogenesis2–6. Their proposed mechanisms of action involve some type of desensitisation of the pituitary to the highly potent LRF analogue and of the gonads to the gonadotropins released in large quantities by the super-LRf, in both target tissues through receptor down-regulation. Another, seemingly unlikely, explanation for the gonadal inhibitory effects of super-LRFs is that the synthetic peptide acts directly at the level of follicular ovarian tissues. Such a direct effect of super-LRF on the gonads has been suggested by the observation that large doses of LRF prevent cultured granulosa cells from aromatising androgens to oestrogens7. We now report that a super-LRF inhibits follicular development in hypophysectomised rats pretreated with pregnant mare serum gonadotropin.
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References
Vale, W., Rivier, C. & Brown, M. A. Rev. Physiol. 39, 473–527 (1977).
Rippel, R. H. & Johnson, E. S. Proc. Soc. exp. Biol. Med. 152, 432–436 (1976).
Johnson, E. S., Gendrich, R. L. & White, W. F. Fert. Steril. 27, 853–860 (1976).
Corbin, A. et al. Fert. Steril. 28, 471–475 (1977).
Dutta, A. S., Furr, B. J. A., Giles, M. B., Valcaccin, B. & Walpole, A. L. Biochem. biophys. Res. Commun. 81, 382–390 (1978).
Rivier, C., Rivier, J. & Vale, W. Endocrinology 103, 2299–2305 (1978).
Hseuh, A. J. W. & Erickson, G. F. Science 204, 854–855 (1975).
Ying, S. H. & Meyer, R. K. Proc. Soc. exp. Biol. Med. 139, 1231–1233 (1972).
Ying, S. H. & Meyer, R. K. Proc. Soc. exp. Biol. Med. 130, 40–43 (1969).
Bradbury, J. Endocrinology 68, 115–120 (1961).
Channing, C. P. Endocrinology 87, 156–164 (1970).
Thanki, K. H. & Channing, C. P. Endocr. Res. Commun. 3, 319–333 (1976).
Channing, C. P., Thanki, K. H. & Lindsey, A. M. in Plasma Membranes, Hormone Action and Reproductive Biology (ed. Birnbaumer, L.) (Plenum, New York, 1978).
Catt, K. J., Bankal, A. J., Davies, T. F. & Dufau, M. L. Endocrinology 104, 17–25 (1979).
Danguy, A. et al. Eur. J. Cancer 13, 1089–1094 (1977).
Lin, Y. C. & Yoshinaga, K. Proc. 58th Mtng Endocrine Soc. 143, abstr. (1976).
Ying, S.-Y. & Guillemin, R. Proc. XIth Int. Congr. Biochemistry (in the press).
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YING, SY., GUILLEMIN, R. (DTrp6-Pro9-NEt)-luteinising hormone-releasing factor inhibits follicular development in hypophysectomised rats. Nature 280, 593–595 (1979). https://doi.org/10.1038/280593a0
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DOI: https://doi.org/10.1038/280593a0
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