Abstract
GLUCOCORTICOIDS are potent anti-inflammatory agents, but the molecular mechanisms involved in this activity are not yet understood. The biological actions of various steroid hormones have been shown to be mediated by functional proteins synthesised following translocation of a hormone-cytoplasmic receptor complex into the nucleus1,2. It is still not clear, however, whether the anti-inflammatory effects of glucocorticoids are mediate via binding to a cytoplasmic receptor in target cells and subsequent activation of gene expression3, although glucocorticoid receptors have been demonstrated in HTC cells, liver5, thymocytes6 and lymphocytes7. The results reported here suggest that a glucocorticoid receptor and the induction of gene expression are involved in the anti-inflammatory action of dexamethasone.
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TSURUFUJI, S., SUGIO, K. & TAKEMASA, F. The role of glucocorticoid receptor and gene expression in the anti-inflammatory action of dexamethasone. Nature 280, 408–410 (1979). https://doi.org/10.1038/280408a0
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DOI: https://doi.org/10.1038/280408a0
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