Abstract
PROTEINS on the cytoplasmic surface of the erythrocyte membrane, including spectrin and actin, are postulated to comprise the red cell cytoskeleton1–3, but little is known about the role of actin or its association with the membrane. We have reported that monomeric (G) actin added to erythrocyte ghosts selectively associates with a component at the cytoplasmic surface of the membrane4,5. We now show that this component is unlikely to be spectrin and that actin binding occurs by stimulated actin polymerisation.
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References
Yu, J., Fischman, D. A. & Steck, T. L. J. supramolec. Struct. 1, 233–248 (1973).
Lux, S. E., John, K. M. & Karnovsky, M. J. J. clin. Invest. 58, 955–963 (1976).
Sheetz, M. P. & Sawyer, D. J. supramolec. Struct. 8, 399–412 (1978).
Cohen, C. M., Jackson, P. L. & Branton, D. J. supramolec. Struct. Suppl. 2, 208 (1978).
Cohen, C. M., Jackson, P. L. & Branton, D. J. supramolec. Struct. 9, 113–124 (1978).
Bennett, V. & Branton, D. J. biol. Chem. 252, 2753–2763 (1977).
Pinder, J. C., Bray, D. & Gratzer, W. Nature 270, 752–754 (1977).
Cohen, C. M. & Branton, D. J. Cell Biol. 79, 262a (1978).
Pollard, T. D. in Molecules and Cell Movement (eds Inoue, S. & Stephens, R. E.) 259–286 (Raven, New York, 1975).
Mooseker, M. S. & Tilney, L. G. J. Cell Biol. 67, 725–743 (1975).
Begg, D. A., Rodewald, R. & Rebhun, L. I. J. Cell Biol. 79, 846–852 (1978).
Edds, K. T. Expl Cell Res. 108, 437–456 (1977).
Nachmias, V. T. & Ash, A. in Cell Motility Vol. 3, (eds Goldman, R., Pollard, T. & Rosenbaum, J.) 771–783 (Cold Spring Harbor, New York, 1976).
Cohen, C. M., Atterbury, B. & Branton, D. (in preparation).
Oosawa, F. & Kasai, M. in Subunits in Biological Systems (eds Timasheff, S. M. & Fasman, G. D.) 261–322 (Marcel Dekker, New York, 1971).
Ungewickell, E. & Gratzer, W. Eur. J. Biochem. 88, 379–385 (1978).
Dunbar, J. C. & Ralston, G. B. Biochim. biophys. Acta 510, 283–291 (1978).
Steck, T. L. & Kant, J. A. Meth. Enzym. 31, 172–180 (1974).
Hosey, M. M. & Tao, M. Biochim. biophys. Acta 482, 348–357 (1977).
Fairbanks, G., Steck, T. L. & Wallach, D. F. H. Biochemistry 10, 2606–2616 (1971).
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COHEN, C., BRANTON, D. The role of spectrin in erythrocyte membrane-stimulated actin polymerisation. Nature 279, 163–165 (1979). https://doi.org/10.1038/279163a0
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DOI: https://doi.org/10.1038/279163a0
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