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Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

Nature volume 277, pages 627–633 (1979)Cite this article

Abstract

A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin γ1 heavy chain was cloned from total cellular DNA. Electron microscopic and nucleotide sequencing studies showed that the three protein domains and the hinge region are encoded in separate DNA segments.

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Authors and Affiliations

  1. Basel Institute for Immunology, 487 Grenzacherstrasse, Postfach, CH-4005, Basel, Switzerland

    Hitoshi Sakano, Konrad Hüppi, Christine Brack, André Traunecker, Richard Maki & Susumu Tonegawa

  2. Molecular Biology Institute and Department of Microbiology and Immunology, School of Medicine, University of California, Los Angeles, California, 90024

    John H. Rogers & Randolph Wall

Authors
  1. Hitoshi Sakano
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  2. John H. Rogers
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  3. Konrad Hüppi
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  4. Christine Brack
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  6. Richard Maki
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  7. Randolph Wall
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  8. Susumu Tonegawa
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Sakano, H., Rogers, J., Hüppi, K. et al. Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments. Nature 277, 627–633 (1979). https://doi.org/10.1038/277627a0

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