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Mechanism of β- adrenergic relaxation of smooth muscle

Naturevolume 277pages3236 (1979) | Download Citation

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Abstract

The mechanism of β-adrenergic relaxation was investigated in isolated smooth muscle cells. β-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.

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References

  1. 1

    Dixon, W. E. J. Physiol., Lond., 30, 97–131 (1903).

  2. 2

    Hoskins, R. G. Am. J. Physiol. 29, 363–366 (1911–12).

  3. 3

    Sutherland, E. W. & Rall, T. W. J. biol. Chem. 232, 1077–1091 (1957).

  4. 4

    Robison, G. A., Butcher, R. W. & Sutherland, E. W. Cyclic AMP (Academic, New York, 1971).

  5. 5

    Rubin, C. S. & Rosen, O. M. A. Rev. Biochem. 44, 831–887 (1975).

  6. 6

    Krebs, E. G. Curr. Topics Cell Regulation 5, 99–133 (1972).

  7. 7

    Nimmo, H. G. & Cohen, P. Adv. Cyclic Nucleotide Res. 8, 145–247 (1977).

  8. 8

    Schultz, G. & Hardman, J. G. in Regulation of Function and Growth of Eukaryotic Cells by Intracellular Cyclic Nucleotides (eds Dumont, J. E., Butcher, R. W. & Brown, B.) (Plenum, New York, 1975).

  9. 9

    Andersson, R. et al. Adv. Cyclic Nudeotide Res. 5, 491–518 (1975).

  10. 10

    Bohr, D. R. Pharmac. Rev. 16, 85–111 (1964).

  11. 11

    Somlyo, A. P. & Somlyo, A. V. Pharmac. Rev. 20, 197–272 (1968).

  12. 12

    Marshall, J. M. & Kroeger, E. A. Phil. Trans. R. Soc. Lond. B265, 135–148 (1973).

  13. 13

    Diamond, J. & Holmes, T. G. Can. J. Physiol. Pharmac. 53, 1099–1107 (1975).

  14. 14

    Kroeger, E. A. & Marshall, J. M. Am. J. Physiol. 226, 1298–1303 (1974).

  15. 15

    Birnbaum, J. E., Abel, P. W., Amidon, G. L. & Buchner, C. K. J. Pharmac. Exp. Ther. 194, 396–409 (1975).

  16. 16

    Born, G. V. R. & Bülbring, E. J. Physiol., Lond. 131, 690–703 (1956).

  17. 17

    Daniel, E. E., Paton, D. M., Taylor, G. S. & Hodgson, B. J. Fedn Proc. 29, 1410–1425 (1970).

  18. 18

    Bose, R. & Bose, D. Am. J. Physiol. 233, C8–C13 (1977).

  19. 19

    Somlyo, A. & Somlyo, A. V. Fedn Proc. 28, 1634–1648 (1969).

  20. 20

    Schild, H. O. Br. J. Pharmac. Chemother. 31, 578–592 (1967).

  21. 21

    Bülbring, E. & Kuriyama, H. Phil. Trans. R. Soc. Lond. B265, 115–121 (1973).

  22. 22

    Kroeger, E. A., Marshall, J. M. & Bianchi, P. J. Pharmac. Exp. Ther. 193, 309–316 (1975).

  23. 23

    Jenkinson, D. H. & Morton, I. K. M. J. Physiol., Lond. 188, 387–402 (1967).

  24. 24

    Fay, F. S. Nature 265, 553–556 (1977).

  25. 25

    Fay, F. S. & Delise, C. M. Proc. natn. Acad. Sci. U.S.A. 70, 641–645 (1973).

  26. 26

    Honeyman, T., Merriam, P. & Fay, F. S. Molec. Pharmac. 14, 86–98 (1978).

  27. 27

    Fay, F. S. & Singer, J. J. Am. J. Physiol. 232, C144–C154 (1977).

  28. 28

    Murray, J. J., Reed, P. W. Fay, F. S. Proc. natn. Acad. Sci. U.S.A. 72, 4459–4463 (1975).

  29. 29

    Fay, F. S. & Taylor, S. R. Biophys. J. 21, 184a (1978).

  30. 30

    Singer, J. J. & Walsh, J. V. in Excitation–Contraction Coupling in Smooth Muscle (eds Casteels, R., Godfraind, T. & Rüegg, J. C. ) (Elsevier, Amsterdam, 1977).

  31. 31

    Walsh, J. V. & J. J. Singer, Nature (submitted).

  32. 32

    Corbin, J. D., Keely, S. L. & Park, C. R. J. biol. Chem. 250, 218–225 (1975).

  33. 33

    Corbin, J. D., Soderling, T. R. & Park, C. R. J. biol. Chem. 248, 1813–1821 (1973).

  34. 34

    Bueding, E., Bülbring, E., Gercken, G., Hawkins, J. T. & Kuriyama, H. J. Physiol., Lond. 193, 187–212 (1967).

  35. 35

    Yoshimura, K. J. Biochem. 74, 389–391 (1973).

  36. 36

    Rogus, M., Cheng, L. C. & Zierler, K. Biochim. Biophys. Acta 464, 347–355 (1977).

  37. 37

    St. Louis, P. J. & Sulakhe, P. V. Eur. J. Pharmac. 43, 277–280 (1977).

  38. 38

    Braughler, J. M. & Corder, C. N. Biochim. Biophys. Acta 524, 455–465 (1978).

  39. 39

    Burnstock, G. J. Physiol., Lond., 143, 183–194 (1958).

  40. 40

    Casteels, R., Droogmans, G. & Hendrickx, H. J. Physiol., Lond. 217, 297–313 (1971).

  41. 41

    El-Sharkawy, T. Y. & Daniel, E. E. Am. J. Physiol. 229, 1277–1286 (1975).

  42. 42

    Marshall, J. M. Fedn. Proc. 36, 2450–2455 (1977).

  43. 43

    Brading, A. F. & Widdicombe, J. H. in Colloquium on Smooth Muscle, Pharmacology and Physiology (eds Worcel, M. & Vassort, G. ) (INSERM, Paris, 1976).

  44. 44

    Reuter, H., Blaustein, M. P. & Haeusler, G. Phil. Trans. R. Soc. Lond. B265, 87–94 (1974).

  45. 45

    Blaustein, M. P. Am. J. Physiol. 232, C165–C173 (1977).

  46. 46

    Ma, T. S. & Bose, D. Am. J. Physiol. 232, C59–C66 (1977).

  47. 47

    Singer, J. J. & Fay, F. S. Am. J. Physiol. 232, C138–C143 (1977).

  48. 48

    Gilman, A. G. Proc. natn. Acad. Sci. U.S.A. 67, 305–312 (1970).

  49. 49

    Hardman, J. G., Mayer, S. E. & Clark, B. J. Pharmac. exp. Ther. 150, 341–348 (1965).

  50. 50

    Keynes, R. D. Proc. R. Soc. Lond. 142, 359–382 (1954).

  51. 51

    Rubin, C. S., Erlichman, J. & Rosen, O. M. Meth. Enzym. 38, 308–315 (1974).

  52. 52

    Ray, T. K. & Forte, J. G. Biochim. biophys. Acta 443, 451–467 (1976).

  53. 53

    Schwartz, A., Lindenmayer, G. E. & Allen, J. C. Pharmac. Rev. 27, 3–134 (1975).

  54. 54

    Jorgensen, P. L. Q. Rev. Biophys. 7, 239–274 (1975).

  55. 55

    Schwartz, A., Allen, J. C. & Harigay, S. J. Pharmac. Exp. Ther. 168, 31–41 (1969).

  56. 56

    Walsh et al. J. biol. Chem. 246, 177–185 (1971).

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  1. Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605

    • C. R. Scheid
    • , T. W. Honeyman
    •  & F. S. Fay

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https://doi.org/10.1038/277032a0

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