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Effect of polarisation of horizontal cells on the on-centre bipolar cell of carp retina

Nature volume 276, pages 399–400 (1978)Cite this article

Abstract

THERE are two types of bipolar cell in the vertebrate retina, the on-centre and the off-centre cells1,2. The on-centre bipolar cells respond with depolarisation to the light spot in the centre of the receptive field and with hyperpolarisation to surround illumination. It is generally assumed that the effect of surround illumination is mediated by horizontal cells, as negative feedback from horizontal cells to photoreceptors has been demonstrated in the turtle retina3. Here we have attempted to clarify the role of horizontal cells in surround antagonism by hyperpolarising horizontal cells by applying extrinsic current in the retina of the carp, Cyprinus carpio. The response of the bipolar cells was similar to that elicited by surround illumination. However, the ionic mechanisms differed depending on the morphological type4 of horizontal cell. An analysis of these mechanisms has led us to conclude that the external horizontal cells receiving inputs exclusively from cones modify the cone-bipolar transmission and the intermediate horizontal cells receiving inputs exclusively from rods modify the rod–bipolar transmission.

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Authors and Affiliations

  1. Department of Physiology, St. Marianna University School of Medicine, Sugao, Takatsu-ku, Kawasaki, 213, Japan

    JUN-ICHI TOYODA & KEIICHI TONOSAKI

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  1. JUN-ICHI TOYODA
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  2. KEIICHI TONOSAKI
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TOYODA, JI., TONOSAKI, K. Effect of polarisation of horizontal cells on the on-centre bipolar cell of carp retina. Nature 276, 399–400 (1978). https://doi.org/10.1038/276399a0

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