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Nucleotide sequence of bacteriophage G4 DNA

Nature volume 276, pages 236–247 (1978)Cite this article

An Erratum to this article was published on 30 November 1978

Abstract

The 5,577 nucleotide long sequence of bacteriophage G4 DNA has been determined using the ‘plus and minus’ and chain termination methods of DNA sequencing. This sequence has been compared with that of the closely related bacteriophage ΦX174 (refs 1, 55). In the coding regions there is an average of 33.1% nucleotide sequence differences between the two genomes, but the distribution of these changes is not random and the sequence of some genes is more conserved than others. There is less sequence similarity between the untranslated intergenic regions of G4 and ΦX174, but despite this the sequences of the J/F, F/G and H/A untranslated spaces in both genomes have similar sized hairpin loops, which may be related to their function.

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Author notes

  1. G. N. Godson

    Present address: Radiobiology Laboratories, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06510

  2. J. C. Fiddes

    Present address: Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK

    G. N. Godson, B. G. Barrell, R. Staden & J. C. Fiddes

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  1. G. N. Godson
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  2. B. G. Barrell
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  3. R. Staden
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  4. J. C. Fiddes
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Godson, G., Barrell, B., Staden, R. et al. Nucleotide sequence of bacteriophage G4 DNA. Nature 276, 236–247 (1978). https://doi.org/10.1038/276236a0

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