Abstract
THE observation1–3 that V(v) is a potent inhibitor of (Na+, K+)-activated renal ATPase raised the possibility that it has natriuretic and thus diuretic properties in the living animal. We report here experiments showing that it has.
Similar content being viewed by others
Article PDF
References
Josephson, L. & Cantley, L. C. Jr Biochemistry 16, 4572–4578 (1977).
Beaugé, L. A. & Glynn, I. M. Nature 272, 551–552 (1978).
Cantley, L. C. Jr, Resh, M. D. & Guidotti, G. Nature 272, 553–554 (1978).
Knight, T. F., Sonsom, S., Harok, L., Frankfurt, S. J. & Weinman, E. J. Eur. J .Physiol. 373, 139–143 (1978).
Hathcock, J. N., Hill, C. H. & Matrone, G. J. Nutr. 82, 106–110 (1968).
Mitchell, W. G. & Floyd, E. P. Proc. Soc. exp. Biol. Med. 85, 206–208 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BALFOUR, W., GRANTHAM, J. & GLYNN, I. Vanadate-stimulated natriuresis. Nature 275, 768 (1978). https://doi.org/10.1038/275768a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/275768a0
This article is cited by
-
Growth and fruitbody formation of Ganoderma lucidum on media supplemented with vanadium, selenium and germanium
Mycoscience (1999)
-
Subchronic treatment with vanadate does not potentiate the toxicity of cardiac glycosides
Biological Trace Element Research (1988)
-
Vanadium in depression and cirrhosis
Journal of Radioanalytical and Nuclear Chemistry Articles (1987)
-
Modulation of apical Na permeability of the toad urinary bladder by intracellular Na, Ca, and H
The Journal of Membrane Biology (1985)
-
Vanadate inhibits urinary acidification by the turtle bladder
Kidney International (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.