Letter | Published:

Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase

Nature volume 274, pages 891893 (31 August 1978) | Download Citation

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Abstract

IN the yeast Saccharomyces cerevisiae a number of mutants potentially defective in DNA replication have been isolated1–3. However, the only defective gene product so far identified in any of these mutants is that in cdc21 which is defective in thymidylate synthetase4,5. We report here that cdc9–l, isolated by Hartwell as a conditional cell cycle mutant6, is defective in a DNA ligase involved in both replication and repair of DNA. A mutant with similar properties has recently been described in Schizosaccharomyces pombe7.

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Author information

Affiliations

  1. Division of Microbiology, National Institute for Medical Research, Mill Hill, London NW7, UK

    • LELAND H. JOHNSTON
  2. Department of Zoology, University of Edinburgh, West Mains Road, Edinburgh, UK

    • KIM A. NASMYTH

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DOI

https://doi.org/10.1038/274891a0

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