Letter | Published:

Are physiological oxygen concentrations mutagenic?

Nature volume 274, pages 606607 (10 August 1978) | Download Citation

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Abstract

HYPERBARIC oxygen is known to be mutagenic towards Escherichia coli1–3. But, can oxygen be mutagenic at tensions physiological to man? We have studied this question using oxygen-sensitive mutants of the histidine auxotroph strain TA100 of Salmonella typhimurium constructed by Ames and his coworkers as part of a test system for carcinogens4. We find that oxygen tensions physiological to higher animals are mutagenic towards these organisms.

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Author information

Affiliations

  1. Department of Biochemistry, University of Oregon Health Sciences Center Portland, Oregon 97201

    • WALTER J. BRUYNINCKX
    •  & HOWARD S. MASON
  2. Department of Microbiology, University of Oregon Health Sciences Center Portland, Oregon 97201

    • STEPHEN A. MORSE
  3. Present address: Laboratorium voor Fysiologische Scheikunde, Faculteit Diergeneeskunde, R.U.G., Casinoplein 24, B-9000, Gent, Belgium.

    • WALTER J. BRUYNINCKX

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DOI

https://doi.org/10.1038/274606a0

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