Abstract
The ability of vitamin A and its analogues (retinoids) to prevent chemically-induced tumours has been studied in various experimental systems1. We have investigated here the possibility that retinoids might also inhibit radiation-induced oncogenic transformation using a cell line of C3H mouse embryo fibroblasts grown in culture. We report a marked reduction in the transformation frequency by using one such compound, Ro-11-1430, the synthesis and structure of which has been described by Bollag2.
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References
Sporn, M. B., Dunlop, N. M. Newton, D. L. & Smith, J. M. Fedn Proc. 35, 1332–1338 (1976).
Bollag, W. Chemotherapia 21, 236–247 (1975).
Reznikoff, C. A., Brankow, D. W. & Heidelberger, C. Cancer Res. 33, 3231–3238 (1973).
Reznikoff, C. A., Bertran, J. S., Brankow, D. W. & Heidelberger, C. Cancer Res. 33, 3239–3249 (1973).
Terzaghi, M. & Little, J. B. Cancer Res. 36, 1367–1374 (1976).
Miller, R. C. & Hall, E. J. Nature 272, 58–60 (1978).
Borek, C. & Sachs, L. Nature 210, 276–278 (1966).
Borek, C. & Hall, E. J. Nature 243, 450–453 (1973); 252, 499–501 (1974).
Trown, P. W., Buck, M. J. & Hansen, R. Cancer Treat. Rep. 60, 1647–1653 (1976).
Bollag, W. Eur. J. Cancer 10, 731–737 (1974).
Chu, E. W. & Malmgren, R. A. Cancer Res. 25, 884–895 (1965).
Saffiotti, U., Montesano, R., Sellakumar, A. R. & Borg, S. A. Cancer 20, 857–864 (1967).
Cone, M. V. & Nettesheim, P. J. natn. Cancer Inst. 50, 1599–1606 (1973).
Moon, R. C., Grubbs, C. J. & Sporn, M. B. Cancer Res. 36, 2626–2630 (1976).
Sporn, M. B. et al. Nature 253, 47–50 (1975).
Lasinitzki, I. & Goodman, D. S. Cancer Res. 34, 1564–1571 (1974).
Chopra, D. P. & Wilkoff, L. J. J. natn. Cancer Inst. 58, 923–930 (1977).
Wilkoff, L. J., Peckham, J. C., Dulmadge, E. A., Mowry, R. W. & Chopra, D. P. Cancer Res. 36, 964–972 (1976).
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HARISIADIS, L., MILLER, R., HALL, E. et al. A vitamin A analogue inhibits radiation-induced oncogenic transformation. Nature 274, 486–487 (1978). https://doi.org/10.1038/274486a0
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DOI: https://doi.org/10.1038/274486a0
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