Abstract
Treatment of Syrian hamster embryo cells with 5-bromodeoxyuridine followed by near ultraviolet irradiation results in neoplastic transformation of these cells. This demonstrates that a direct perturbation of DNA is sufficient to initiate neoplastic transformation.
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Barrett, J., Tsutsui, T. & Ts'o, P. Neoplastic transformation induced by a direct perturbation of DNA. Nature 274, 229–232 (1978). https://doi.org/10.1038/274229a0
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DOI: https://doi.org/10.1038/274229a0
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