Abstract
P815 cells spontaneously shed material (exfoliate) in which actin is the major protein. The exfoliate also contains H–2. The association between actin and H–2 is stable even in the presence of detergent, indicating that protein–protein interactions exist between the actin and H–2. The exfoliate probably consists of highly purified microvilli.
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References
Berlin, R. D., Oliver, J. M., Ukena, T. E. & Yin, H. H. Nature 247, 45–46 (1974).
Nicolson, G. L. Biochim. biophys. Acta 457, 57–108 (1976).
Edelman, G. M. Science 192, 218–226 (1976).
Raff, M. C. Scient. Am. 234, 30–39 (1976).
Greaves, M. & Janossy, G. Transplantation 11, 87–103 (1972).
Andersson, J., Edelman, G. M., Möeller, G. & Sjoberg, O. Eur. J. Immun. 2, 233–235 (1972).
Taylor, R. B., Duffus, W. P. H., Raff, M. C. & de Petris, S. Nature new Biol. 233, 225–229 (1971).
Sundquist, K. G. & Ehrnst, A. Nature 264, 226–231 (1976).
Toh, B. G. & Hard, G. C. Nature 269, 695–697 (1977).
Gabbiani, G., Chapponier, C., Zumbe, A. & Vassalli, P. Nature 269, 697–698 (1977).
Bourguignon, L. Y. W. & Singer, S. J. Proc. natn. Acad. Sci. U.S.A. 74, 5031–5035 (1977).
Bonneville, M. A. & Weinstock, M. J. Cell Biol. 44, 151–171 (1970).
Brunser, O. & Luft, J. H. J. ultrastruct. Res. 31, 291–311 (1970).
Mukherjee, T. M. & Staehlin, L. H. J. Cell Sci. 8, 573–599 (1971).
Overton, J. & Shoup, J. J. Cell Biol. 26, 693–706 (1964).
Tilney, L. G. & Cardell, R. R. Jr, J. Cell Biol. 47, 408–422 (1970).
Huxley, H. E. Nature 243, 445–449 (1973).
Pollard, T. D. & Korn, E. D. Cold Spring Harb. Symp. quant. Biol. 37, 573–583 (1972).
Pollard, T. D. & Weihing, R. R. Crit. Rev. Biochem. 2, 1–65 (1974).
Spudich, J. A. J. biol. Chem. 249, 6013–6020 (1974).
Mooseker, M. S. & Tilney, L. G. J. Cell Biol. 67, 725–743 (1975).
Lazarides, E. & Burridge, K. Cell 6, 289–298 (1975).
Springer, T. A. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 73, 2481–2485 (1976).
Walsh, F. S. & Crumpton, M. J. Nature 269, 307–311 (1977).
Dunn, T. O. & Potter, M. J. natn. Cancer Inst. 18, 587–601 (1957).
Frye, C. D. & Edidin, M. J. Cell Sci. 7, 313–333 (1970).
Stackpole, C. W. et al. Science 172, 472–474 (1971).
Knutton, S., Sumner, M. C. B. & Pasternak, C. A. J. Cell Biol. 66, 568–576 (1975).
Cone, R. E. in The Lymphocyte: Structure and Function vol. 2 (ed. Marchalonis, J. J.) 565–592 (Dekker, New York, 1977).
Flanagan, J. & Koch, G. L. E. Nature 273, 278–281 (1978).
Atkinson, P. H. & Summers, D. F. J. biol. Chem. 246, 5162–5175 (1971).
O'Farrell, P. H. J. biol. Chem. 250, 4007–4021 (1975).
Laemmli, U. K. Nature 222, 680–685 (1970).
Robinson, P. J., Bull, F. G., Anderton, B. H. & Roitt, I. M. FEBS Lett. 58, 330–333 (1975).
Wigzell, H. Transplantation 3, 423–431 (1965).
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Koch, G., Smith, M. An association between actin and the major histocompatibility antigen H–2. Nature 273, 274–278 (1978). https://doi.org/10.1038/273274a0
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DOI: https://doi.org/10.1038/273274a0
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