Abstract
THERE is remarkably little information about the possible importance of cell-mediated immune responses in the protection of hosts during influenza virus infection. It has recently been found that specific cytotoxic T cells (Tc) can be recovered from the spleens of mice previously inoculated intranasally or intravenously with live virus1–4 and peak activity occurs about 6 d after virus inoculation. Furthermore, Tc are found in the lungs and the lymph nodes draining the lungs of infected mice in conditions which suggest that these cells might be important in host recovery from this infection5. Adoptive transfer of primary or secondary immune spleen cells to mice inoculated intranasally with a lethal dose of A/WSN virus caused a significant reduction of infectious virus levels in the lungs and prevented death6. The active cells in the transferred population were T lymphocytes. This report shows that the protective effects conferred by the transferred T cells in these conditions are largely, if not entirely, due to Tc.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Yap, K. L. & Ada, G. L. Immunology, 32, 151–169 (1977).
Effros, R. B., Doherty, P. C., Gerhard, W. & Bennink, J. J. exp. Med. 145, 557–568 (1977).
Braciale, T. J. Cell Immun. 33, 433–436 (1977).
Zweerink, H. J. Courtneidge, S. A., Skehel, J. J., Crumpton, M. J. & Askonas, B. A. Nature 267, 354–356 (1977).
Yap, K. L. & Ada, G. L. Scand. J. Immun. 7, 73–80 (1978).
Yap, K. L. & Ada, G. L. Scand. J. Immun. (in the press).
Pang, T., McKenzie, I. F. C. & Blanden, R. V. Cell. Immun. 26, 153–159 (1976).
Beverley, P. C. R., Woody, J., Dunkley, M., Feldmann, M. & McKenzie, I. F. C. Nature 262, 495–497 (1976).
Feldmann, M., Beverley, P. C. R., Woody, J. & McKenzie, I. F. C. J. exp. Med. 145, 793–805 (1977).
Cantor, H. & Boyse, E. A. J. exp. Med. 141, 1376–1389 (1975).
Erb, P. & Feldmann, M. J. exp. Med. 142, 460–472 (1975).
Katz, D. H. & Benacerraf, B. Transplantn Rev. 22, 175–195 (1975).
Miller, J. F. A. P., Vadas, M. A., Whitelaw, A. & Gamble, J. Proc. natn. Acad. Sci. U.S.A. 72, 5095–5098 (1975).
Doherty, P. C., Blanden, R. V. & Zinkernagel, R. Transplantn Rev. 29, 89–124 (1976).
Kees, U. & Blanden, R. V. J. exp. Med. 143, 450–455 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
YAP, K., ADA, G. & MCKENZIE, I. Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature 273, 238–239 (1978). https://doi.org/10.1038/273238a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/273238a0
This article is cited by
-
Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study
npj Vaccines (2020)
-
Cutaneous Dengue Virus Inoculation Triggers Strong B Cell Reactions but Contrastingly Poor T Cell Responses
Virologica Sinica (2020)
-
Extending the Breadth of Influenza Vaccines: Status and Prospects for a Universal Vaccine
Drugs (2018)
-
Influenza‐induced lung Trm: not all memories last forever
Immunology & Cell Biology (2017)
-
Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies
Scientific Reports (2016)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.