Abstract
Details of the stereochemistry of the 2′5′ and 3′5′ dinucleoside monophosphates of polynueleotides have been delineated in aqueous solution using nuclear magnetic resonance spectroscopy. Incorporation of these experimentally determined geometries into the structure of polynueleotides reveals that the intrinsic spatial configurations of the 2′5′ bonds cannot support helical structures whereas the geometries of 3′5′ bonds allow the formation of helical configurations for RNA.
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References
Lee, C. H., Ezra, F. S., Kondo, N. S., Sarma, R. H. & Danyluk, S. S. Biochemistry 15, 3627–3639 (1976).
Ezra, F. S., Lee, C. H., Kondo, N. S., Danyluk, S. S. & Sarma, R. H. Biochemistry 16, 1977–1987 (1977).
Cheng, D. M. & Sarma, R. H. J. Am. chem. Soc. 99, 7333–7348 (1977).
Sarma, R. H. & Danyluk, S. S. J. Quantum Chem. 4, 269–276 (1977).
Evans, F. E. & Sarma, R. H. Nature 263, 567–572 (1976).
Kondo, N. S., Holmes, H. M., Stempel, L. M. & Ts'o, P. O. P. Biochemistry 9, 3479–3498 (1970).
Schleich, T., Cross, B. P. & Smith, I. C. P. Nucleic Acids Res. 3, 355–370 (1976).
Ezra, F. S., Kondo, N. S., Ainsworth, C. F. & Danyluk, S. S. Nucleic Acids Res. 3, 2549–2562 (1976).
Perahia, D., Pullman, B. & Saran, A. Biochim. biophys. Acta 353, 16–27 (1974).
Rubin, J., Brennan, T. & Sundaralingam, M. Biochemistry 11, 3112–3128 (1972).
Imoto, T., Akasaka, A. & Hatano, H. Chem. phys. Lett. 32, 86–89 (1975).
Lee, C. H. & Sarma, R. H. Biochemistry 15, 697–704 (1976).
Lee, C. H., Sarma, R. H. J. Am. chem. Soc. 98, 3541–3548 (1976).
Kim, S. H., Berman, H. M., Seeman, N. C. & Newton, M. D. Acta crvstallogr. B 29, 703–710 (1973).
Sundaralingam, M. The Jerusalem Symposia on Quantum Chemistry and Biochemistry 5, 417–455 (1973).
Giessner-Pettre, C., Pullman, B., Borer, P. N., Kan, L. S. & Ts'o, P. O. P. Biopolymers 15, 2277–2286 (1976).
Rosenberg, M. et al. Nature 243, 150–154 (1973).
Sussman, J. L., Seeman, N. C., Kim, S. H. & Berman, H. M. J. molec. Biol. 66, 403–415 (1972).
Hingerty, B. et al. Biopolymers 14, 227–236 (1975).
Rosenberg, J. M., Seeman, N. C., Day, R. O. & Rich, A. J. molec. Biol. 104, 145–167 (1976).
Seeman, N. C., Rosenberg, J. M., Suddath, F. L., Kim, J. J. P. & Rich, A. J. molec. Biol. 106, 109–144 (1976).
Seeman, N. C., Sussman, J. L. & Berman, H. M. Nature New Biology, 233, 90–92 (1971).
Imoto, T., Akasak, A. & Hatano, H. Chem. Lett. 73–74 (1974).
Son, T. D. & Chachaty, C. Biochim. biophys. Acta 335, 1–13 (1973).
Shefter, E., Barlow, M., Sparks, R. A. & Trueblood, K. N. Acta crystallogr. B 25, 895–909 (1969).
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Dhingra, M., Sarma, R. Why do nucleic acids have 3′5′ phosphodiester bonds?. Nature 272, 798–801 (1978). https://doi.org/10.1038/272798a0
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DOI: https://doi.org/10.1038/272798a0
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