Letter | Published:

α-Bungarotoxin enhances transmitter ‘released’ at the neuromuscular junction

Nature volume 272, pages 641643 (13 April 1978) | Download Citation

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Abstract

α-BuNGAROTOXIN (α-BTX), a neurotoxin obtained from the venom of the snake Bungarus multicinctus, blocks neuromuscular transmission by combining irreversibly with the acetylcholine (ACh) receptors located in the postsynaptic membrane1–4. The results reported here show that α-BTX also causes an increase in the amount of ACh collected after nerve stimulation.

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Author information

Affiliations

  1. Department of Biophysics, University College London, Gower Street, London WC1, UK

    • R. MILEDI
  2. Sylvius Laboratories, University of Leiden, 72 Wassenaarseweg, Leiden, The Netherlands

    • P. C. MOLENAAR
  3. Medical Biological Laboratory/TNO, Lange Kleiweg, Rijswijk Z. H., The Netherlands

    • R. L. POLAK

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https://doi.org/10.1038/272641a0

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