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Enhancement of carcinogenesis by prostaglandins

Nature volume 272, pages 634–636 (1978)Cite this article

Abstract

INCREASED amounts of prostaglandins, especially prostaglandin (PG) E2 (PGE2), have been detected in human cancer tissue as well as in cultured mouse fibrosarcoma cells1. Elevated prostaglandin synthetase activity has also been found in microsomal fractions of transformed cells from methylcholanthrene-treated mice2. In investigations of the role of PGE2 and PGF2a on skin tumours induced by 3-methylcholanthrene (MCA) in mice, I report here evidence that these prostaglandins can act as cocarcinogens.

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References

  1. Jaffe, B. Prostaglandins 6, 453–461 (1974).

    Article  CAS  Google Scholar 

  2. Hong, S., Wheless, C. & Levine, L. Prostaglandins 13, 271–279 (1977).

    Article  CAS  Google Scholar 

  3. Lupulescu, A. Prostaglandins 10, 573–579 (1975).

    Article  CAS  Google Scholar 

  4. VanDuuren, B. in Chemical Carcinogens (ed. Searle, C) 24–51 (Am. Chem. Soc. Washington, D.C. 1976).

    Google Scholar 

  5. Furth, J. Fedn Proc. 20, 865–873 (1961).

    CAS  Google Scholar 

  6. Smythies, J., Benington, F. & Morin, R. Psyclwneuroendocrinology 1, 123–130 (1975).

    Article  CAS  Google Scholar 

  7. Bennett, A., Simpson, J., McDonald, A. & Stamford, I. Lancet i, 1218–1220 (1975).

    Article  Google Scholar 

  8. Powles, T., Dowsett, M., Easty, G., Easty, D. & Neville, A. Lancet i, 608–610 (1976).

    Article  Google Scholar 

  9. Jimenez de Asua, L., Clingan, D. & Rudland, P. Proc. natn. Acad. Sci. U.S.A. 72, 2724–2728 (1975).

    Article  ADS  CAS  Google Scholar 

  10. Lupulescu, A. & Pinkus, H. Oncology 33, 24–28 (1976).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Medical Research Building, Wayne State University, Detroit, Michigan, 48201

    A. LUPULESCU

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  1. A. LUPULESCU
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LUPULESCU, A. Enhancement of carcinogenesis by prostaglandins. Nature 272, 634–636 (1978). https://doi.org/10.1038/272634a0

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