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Enhancement of carcinogenesis by prostaglandins

Naturevolume 272pages634636 (1978) | Download Citation



INCREASED amounts of prostaglandins, especially prostaglandin (PG) E2 (PGE2), have been detected in human cancer tissue as well as in cultured mouse fibrosarcoma cells1. Elevated prostaglandin synthetase activity has also been found in microsomal fractions of transformed cells from methylcholanthrene-treated mice2. In investigations of the role of PGE2 and PGF2a on skin tumours induced by 3-methylcholanthrene (MCA) in mice, I report here evidence that these prostaglandins can act as cocarcinogens.

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  1. Medical Research Building, Wayne State University, Detroit, Michigan, 48201



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