Letter | Published:

Human pulmonary alveolar macrophages metabolise benzo(a)pyrene to proximate and ultimate mutagens

Nature volume 272, pages 633634 (13 April 1978) | Download Citation

Subjects

Abstract

PULMONARY alveolar macrophages (PAM) phagocytose inhaled foreign particulates that reach the peripheral airways. Particulates engulfed by PAM are then transported by the mucociliary system up the respiratory tract past the bronchial epithelium to be expectorated and/or swallowed. Since these particulates may contain adsorbed chemical carcinogens, for example, those in tobacco smoke, and PAM have been shown to metabolise chemical carcinogens1–3, PAM may interact with the bronchial epithelium in the metabolic activation of respiratory carcinogens. We report here the metabo-lic activation of benzo(a)pyrene (B(a)P) by PAM into both a promutagen ( ± )r7,t8-dihydroxy-7,8-dihydrobenzo(a)pyrene; (7,8-diol; 50% ( + )) and an ultimate mutagen(s).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & J. clin. Invest. 52, 1881–1884 (1973)

  2. 2.

    Zentralbl. Bakteriol. (Orig. B) 161, 1–19 (1975).

  3. 3.

    et al. Lab. Invest. (in press).

  4. 4.

    & Int. J. Cancer 13, 326–333 (1974).

  5. 5.

    & Genetics 61, 1306–1312 (1968).

  6. 6.

    , , & Proc. natn. Acad. Sci. U.S.A. 73, 607–611 (1976).

  7. 7.

    et al. Cancer Res. 37, 3349–3356 (1977).

  8. 8.

    , , & Cancer Res. 34, 3474–3480 (1974).

  9. 9.

    , & Cell 3, 221–226 (1974).

  10. 10.

    Am. Rev. resp. Dis. 116, 73–122 (1977).

  11. 11.

    Brain, J. D., Proctor, D. F. & Reid, L. M. (ed.) Respiratory Defense Mechanism, Part II (Marcel Dekker, New York, 1977).

  12. 12.

    , , , & Nature 266, 378–380 (1977).

  13. 13.

    , , , & Cancer Res. 37, 1210–1215 (1977).

Download references

Author information

Affiliations

  1. Human Tissue Studies Section, Experimental Pathology Branch, Carcinogenesis Research Program, National Cancer Institute, Bethesda, Maryland 20014

    • CURTIS C. HARRIS
    • , IH CHANG Hsu
    •  & GARY D. STONER
  2. Department of Pathology, School of Medicine, University of Maryland, Baltimore, Maryland 21201

    • BENJAMIN F. TRUMP
  3. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

    • JAMES K. SELKIRK

Authors

  1. Search for CURTIS C. HARRIS in:

  2. Search for IH CHANG Hsu in:

  3. Search for GARY D. STONER in:

  4. Search for BENJAMIN F. TRUMP in:

  5. Search for JAMES K. SELKIRK in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/272633a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.