Abstract
ABOUT two-thirds of the excess leukaemia in adult Japanese survivors of the atomic bombs is myeloid in type (acute plus chronic)1. Nevertheless, most of the extensive experimental work on leukaemia induction by ionising radiation in the past 25 yr has been concerned with the thymic leukaemia of the laboratory mouse2, a disease which may have no human counterpart. So far, only one series of systematic experiments has been reported on myeloid leukaemia in irradiated mice3,4, and this concerned RF mice, a strain which has this disease in the relatively high frequency of 2–6% in unirradiated controls. Single brief whole-body X-ray exposures have now proved to be effective in inducing myeloid leukaemia in male CBA/H mice, provided that the radiation dose is not too great. This possibly provides an important model for quantitative investigation of carcinogenic mechanisms and for use in the development of chemotherapy for the analogous human disease.
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MAJOR, I., MOLE, R. Myeloid leukaemia in X-ray irradiated CBA mice. Nature 272, 455–456 (1978). https://doi.org/10.1038/272455a0
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DOI: https://doi.org/10.1038/272455a0
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