Abstract
I SUGGEST that if different cell types have different glycoprotein coatings they will tend to adhere to each other with different intensities, and sort out into separate tissues simply as a result of weak nonspecific interactions between the glycoproteins without any special mechanisms such as binding by specific recognition proteins. This could be responsible for many, but certainly not all, cell recognition and adhesion phenomena (reviewed in refs 1 and 2).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Marchase, R. B., Vosbeck, K. & Roth, S. Biochim. biophys. Acta 457, 385–416 (1976).
Glaser, L. Trends Biochem. Sci. 1, 84–86 (1976).
Albertsson, P-Å. Partition of Cell Particles and Macromolecules (Wiley, New York, 1960).
Flory, P. J. Principles of Polymer Chemistry (Cornell University Press, Ithaca, New York, 1953).
Edmond, E. & Ogston, A. G. Biochem. J. 109, 569–576 (1968).
Ogston, A. G. in Chemistry and Molecular Biology of the Intercellular Matrices (ed. Balazs, E. A.) Vol. 3, 1231–1240 (Academic, London and New York, 1970).
Baserga, R. Multiplication and Division in Mammalian Cells (Marcel Dekker, New York and Basel, 1976).
Moyer, W. A. & Steinberg, M. S. Devl Biol. 52, 246–262 (1976).
Greenbury, C. L., Moore, D. H. & Nunn, L. A. C. Immunology 6, 421–433 (1963).
Steck, T. L. J. Cell Biol. 62, 1–19 (1974).
Ashwell, G. & Morell, A. G. Trends Biochem. Sci. 2, 76–78 (1977).
Steinberg, M. S. in Cellular Membranes in Development (ed. Locke, M.) 321–366 (Academic, New York, 1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
EDWARDS, P. Differential cell adhesion may result from nonspecific interactions between cell surface glycoproteins. Nature 271, 248–249 (1978). https://doi.org/10.1038/271248a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/271248a0
This article is cited by
-
Cell adhesion in the life cycle ofDictyostelium
Experientia (1995)
-
Effect of different proteins on proteoglycan induced erythrocyte aggregation
Bulletin of Experimental Biology and Medicine (1991)
-
Role of heparin in red cell aggregation
Bulletin of Experimental Biology and Medicine (1986)
-
Current ideas on the significance of protein glycosylation
Molecular and Cellular Biochemistry (1986)
-
Glycolipid modulation of membrane adhesion
Neurochemical Research (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
