Abstract
THE disadvantages encountered with radioisotopes, such as high costs, health hazards, limited variety of useable isotopes, short shelf-life of the labelled antigens and difficulties of introducing the radioactive isotope on to the antigen molecule, have stimulated the search for non-isotopic methods in immunological work1. We report here on the feasibility of a novel non-isotopic system for immunochemical studies and its possible use in immunoassays. The basic concept of the new system is the use of metal atoms in the form of their organometallic or co-ordination complexes as labelling agents for haptens or macromolecular antigens.
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CAIS, M., DANI, S., EDEN, Y. et al. Metalloimmunoassay. Nature 270, 534–535 (1977). https://doi.org/10.1038/270534a0
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DOI: https://doi.org/10.1038/270534a0
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