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Human and mouse embryonal carcinoma cells in culture share an embryonic antigen (F9)


THE embryonic membrane antigen F9 has been detected on several lines of mouse embryonal carcinoma (EC) cells as well as on mouse embryos and sperm, but not on any other adult cells tested1. F9 or an antigenically similar substance has been demonstrated on the morula and/or sperm of several mammalian species2 including man3, but has been undetectable in all nonmammalian species tested2. Although no function for this antigen has been identified, its restriction to embryonic and germ cells suggests an important developmental role. This possibility is enhanced by the apparent conservation of F9 in the course of evolution. We now report the serological detection of F9 on human EC, together with our inability to detect β2 microglobulin.

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HOLDEN, S., BERNARD, O., ARTZT, K. et al. Human and mouse embryonal carcinoma cells in culture share an embryonic antigen (F9). Nature 270, 518–520 (1977).

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