Abstract
THE specific binding of high-affinity ligands to a wide range of pharmacological receptors has been used to obtain information on receptor numbers, distribution and the characteristics of agonist and antagonist binding. The first study of this type, by Paton and Rang1, was of the binding of 3H-atropine to muscarinic receptors in guinea pig intestinal smooth muscle. The histamine H1 receptor has not previously been studied, and here we describe the specific binding of mepyramine, an H1-selective antagonist2, to histamine H1 receptors in homogenates of the longitudinal muscle-myenteric plexus preparation from guinea pig small intestine.
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HILL, S., YOUNG, J. & MARRIAN, D. Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle. Nature 270, 361–363 (1977). https://doi.org/10.1038/270361a0
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DOI: https://doi.org/10.1038/270361a0
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