Abstract
MANY hormones exist in several molecular forms. The intestinal hormone cholecystokinin has been isolated from hog duodenum in the form of peptides of 33 and 39 amino acid residues (CCK33 and CCK39)1–4. Extracts of hog cerebral cortex have been shown to contain components with CCK-like immunoreactivity5, but on gel filtration the main component in brain had the properties of the COOH-terminal octapeptide (CCK8) of CCK33 and CCK395. Several other hormonal and related peptides probably occur in identical forms in brain and gut6, so it seemed possible that a CCK8-like factor would also be found in intestine. Synthetic CCK8 is known to be about twice as potent on a molar basis as CCK33 on the main target organs of the hormone (gall bladder and exocrine pancreas)7 so that the possible existence of CCK8 in the intestine is of physiological significance. We have studied immunoreactive CCK-like factors in extracts of hog duodenum and jejunum and we report here the presence of relatively high concentrations of a CCK8-like component. This factor was poorly extracted by the method used to purify CCK33 and CCK39 which may explain why it was previously overlooked.
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DOCKRAY, G. Immunoreactive component resembling cholecystokinin octapeptide in intestine. Nature 270, 359–361 (1977). https://doi.org/10.1038/270359a0
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DOI: https://doi.org/10.1038/270359a0
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