Abstract
CERTAIN experimental manifestations of plasticity, such as habituation1–3 and long-term potentiation2,4–6, can be readily demonstrated at the perforant path-granule cell synapse in the fascia dentata, and these adaptations are believed to have behavioural counterparts. The perforant path–granule cell synapse may thus serve as a model for investigating the simplest components of behaviour and intellectual function. Detailed studies would, however, require knowledge of the transmitter used by the perforant path fibres. Quite apart from the problem of synaptic plasticity, identification of the perforant path transmitter would add substantially to our knowledge of excitatory transmitters in the central nervous system. Here we present pre- and postsynaptic evidence that these fibres use glutamate as their transmitter.
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WHITE, W., NADLER, J., HAMBERGER, A. et al. Glutamate as transmitter of hippocampal perforant path. Nature 270, 356–357 (1977). https://doi.org/10.1038/270356a0
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DOI: https://doi.org/10.1038/270356a0
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