Abstract
THE persistence of the centriole during interphase near the nucleus within the so-called cell centre seems to be a general feature of most animal cells. An association between the nucleus and the cell centre has been proposed and has been clearly shown in some cell types1,2. A permanent system involving chromosomes, spindle fibres and centrioles has been suggested by Lettre et al.3, and Aronson4 has demonstrated the existence of a Colcemid-sensitive mobile system between the nucleus and a centre at the two-cell stage in the sea urchin Lytechinus variegatus. We show here that there is a physical association between the centriole and the nucleus in the rat liver cell which resists cold treatment, cell disruption and nuclear isolation. When nuclear envelopes are prepared from isolated nuclei, the association between the centriole and the nuclear envelope is maintained.
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BORNENS, M. Is the centriole bound to the nuclear membrane?. Nature 270, 80–82 (1977). https://doi.org/10.1038/270080a0
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DOI: https://doi.org/10.1038/270080a0
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