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Recent excitement in the DNA replication problem

Nature volume 269, pages 655–661 (1977)Cite this article

Abstract

It is now possible to reproduce most of the reactions involved in DNA replication using prokaryotic enzymes in vitro. Such systems have revealed that DNA replication is a complex process depending on a relatively large number of proteins, and that nucleoside triphosphate hydrolysis energy is used at several discrete steps. Much of the complexity of DNA replication may arise from the need for extreme copying fidelity.

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  1. Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143

    Bruce Alberts

  2. Department of Biochemistry, State University of New York, Stony Brook, New York, 11794

    Rolf Sternglanz

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Alberts, B., Sternglanz, R. Recent excitement in the DNA replication problem. Nature 269, 655–661 (1977). https://doi.org/10.1038/269655a0

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