Abstract
WATKINS1 reported that sheep red blood cells coated with anti-sheep-red blood cell antibody adsorbed to monolayers of herpes simplex virus (HSV) infected cells. Yasuda and Milgrom2 suggested that the haemadsorption was mediated through an Fc-binding site which developed on the surface of the HSV infected cell, and later work from Watkin's laboratory established this interpretation3. Although the receptor for the Fc portion of IgG on the surface of HSV infected cells has been known for some time, its biological role remains unclear4,5. We show here that when the HSV-induced Fc receptor is engaged with IgG or Fc fragments, viral replication is significantly inhibited.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Watkins, J. F. Nature 202, 1364 (1964).
Yasuda, J. & Milgrom, F. Int. Arch. Allergy 33, 151 (1968).
Westmoreland, D. & Watkins, J. J. gen. Virol. 24, 167 (1974).
Costa, J. C. & Rabson, A. S. Lancet i, 77 (1975).
Lehner, T., Wilton, J. M. A. & Shillitoe, E. J. Lancet ii, 60 (1975).
Costa, J., Yee, C., Troost, T. & Rabson, A. Nature 252, 745 (1974).
Reid, T. W. et al. J. natn. Cancer Inst. 53, 347 (1974).
Reynolds, H. Y., Atkinson, J. P., Newball, H. H. & Frank, M. M. J. Immun 114, 1813 (1975).
Jaffe, E. S., Shevach, E. M., Frank, M. M., Berard, C. W. & Green, J. New Engl. J. Med. 290, 813 (1974).
Prahl, J. W. Biochem. J. 104, 647 (1967).
Huber, C. H., Sundstrom, C., Nilsson, K. & Wigzell, H. Clin. exp. Immun. 25, 367 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
COSTA, J., RABSON, A., YEE, C. et al. Immunoglobulin binding to herpes virus-induced Fc receptors inhibits virus growth. Nature 269, 251–252 (1977). https://doi.org/10.1038/269251a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/269251a0
This article is cited by
-
Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells
Gene Therapy (2003)
-
Inhibition of antibody-dependent cell-mediated cytolysis of tumor cells by Fc receptor of human cytomegalovirus
Archives of Virology (1987)
-
Differences in antigenic properties of Fc-binding activity during infection with herpes simplex virus type 1
Archives of Virology (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
